The Real Science of Weight Loss with Dr. Mike Israetel

American Glutton

Health & Fitness

4.9 • 3K Ratings

🗓️ 1 December 2025

⏱️ 93 minutes

🔗️ Recording | iTunes | RSS

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Summary

What if everything you believe about dieting and weight loss is wrong?

Ethan Suplee sits down with Dr. Mike Israetel for a brutally clear look at fad diets, sustainable fat loss, and the real science behind building muscle while dropping weight. They talk through keto myths, progressive overload, food psychology, and why modern life is designed to make you overeat. If you have ever felt stuck or confused by conflicting nutrition advice, this episode cuts through the noise.

SHOW HIGHLIGHTS

00:00 The Keto Mistake Ethan Discovered

02:45 What Mike’s TED Talk Changed

06:07 Progressive Overload Explained Simply

12:47 What Failure in Training Really Means

17:32 How Beginners Should Actually Train

20:30 Muscle vs Fat and Why Muscle Matters

23:26 Why Muscle Improves Metabolic Health

27:07 Why Overweight People Often Excel at Lifting

29:23 Why Fad Diets Set You Up for Failure

32:46 The Danger of One Size Fits All Diets

35:59 Hunger, Evolution and Modern Food

41:21 The Red Pill of Understanding Food

45:56 Why Food Is Not Moral or Immoral

48:30 The Forbidden Food Effect

52:13 Ethan Reintroduces Carbs and Freaks Out

53:55 Why Boring Science Wins in the End

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Transcript

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0:00.0	I want to take one minute and talk to you about three things. The first is Substack. I'm on Substack.
0:06.7	I'm writing longer form things and I'm having incredible conversations with my subscribers. So check it out.
0:12.4	Go to EthanSupple.com and join in on the conversation. We want your voice heard there too.
0:20.4	That's one.
0:21.4	The second thing is the prep deck.
0:22.8	Do you have your prep deck?
0:24.5	The prep deck is an incredible tool
0:26.6	that takes the guesswork out of meal planning.
0:29.1	I have diet fatigue.
0:30.4	My wife has diet fatigue.
0:32.2	We go to the prep deck and we allow the deck
0:34.5	to choose what we eat for us.
0:36.6	It's a wonderful resources.
0:39.0	So if you don't have one, grab yours today.
0:41.3	And finally, American Glutton has protein powder.
0:45.8	You can get a 25 gram dose of protein throughout the day in delicious chocolate and vanilla flavors.
0:52.6	So go to Americanglutton.net and get your protein powder today.
0:57.9	Hi, I'm Ethan Soply.
1:00.1	Welcome to American Glutton.
1:02.0	Outside of acting, my two favorite things to do are diet and eat.
1:05.9	I have a very complicated relationship with food,
1:08.3	and on this podcast, we're going to talk about all of it.
	...

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