The Primal Menopausal Diet & Rewriting Women’s Longevity | Dr. Mindy Pelz

The Art of Being Well

Dear Media, Will Cole

Theartofbeingwell, Health & Fitness, Drwillcole, Dear, Doctor, Media, Dr, Cole, Will

4.7 • 1.2K Ratings

🗓️ 11 December 2025

⏱️ 62 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

In this episode, Dr. Will Cole sits down with bestselling author and women’s health expert Dr. Mindy Pelz to talk about the misunderstood science of menopause, longevity, and metabolic flexibility. Dr. Pelz breaks down why women can’t “biohack” their way through midlife, how estrogen impacts over a dozen neurochemicals, why irritability and brain fog are often neurological - not just hormonal - and why the menopausal brain shifts to preferring ketones over glucose. They also explore the Primal Menopausal Diet, fasting windows, lifestyle shifts that naturally rebalance neurotransmitters, and how to step into the innate leadership encoded into the female brain post-menopause. For all links mentioned in this episode, visit http://www.drwillcole.com/podcast

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Transcript

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0:00.0	The following podcast is a dear media production.
0:05.3	Hi, it's Dr. Will Cole.
0:09.1	This podcast is the manifesto for a new breed of health seekers.
0:15.1	This is the art of Being Well.
0:28.4	What's up and welcome to The Art of Being Well?
0:32.9	My friends, at the time of recording this, I have some exciting news.
0:41.4	The wait list for my one-on-one concierge telehealth console, online consult, is now open for myself and for my functional medicine telehealth team, or you know some of them from the Ask Me Anything
0:48.2	episodes. So if you want to learn more about the different type of cases we're taking on right now
0:53.4	and the different ways that
0:55.0	we are there for people around the world. You could check it out at Dr.willcolle.com. That's
1:00.2	Dr.W-I-L-C-O-L-C-O-E.com. Head on over to the Become a Patient Consultation page
1:06.7	to learn more about the different paths for different people and the type of health issues
1:11.4	that we're helping people overcome and optimize. Okay, let's get to today's guest. Her name
1:16.8	is Dr. Mindy Pels. Today I sit down with the legendary Dr. Mindy Pels. And we discuss what truly
1:24.5	happens inside the female brain and body during perimenopause and menopause.
1:30.0	Dr. Pels explains how estrogen acts as a master regulator for more than a dozen neurochemicals,
1:37.0	including dopamine, serotonin, GABA, and acetylcholine, and why its natural decline reshapes
1:42.9	motivation, mood, sleep, cognition, and identity.
1:46.7	We unpack why irritability and brain fog are neurological signals, not personal flaws,
1:52.0	why ketones become the preferred fuel for the menopausal brain, and how fasting, novelty,
1:58.7	storytelling, tuber-rich foods,
2:01.1	and circadian alignment can naturally restore balance.
	...

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