The PREDIMED Trial – Controversy, Criticisms, & Lessons Learned (SNP 22)
Sigma Nutrition Radio
Danny Lennon
4.8 • 633 Ratings
🗓️ 17 October 2023
⏱️ 18 minutes
🧾️ Download transcript
Summary
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About This Episode:
PREDIMED (Prevención con Dieta Mediterránea) is a landmark clinical trial conducted in Spain.
The study made a huge splash due to the rarity in nutrition of having large RCTs with hard endpoints. In addition, it had results of a large magnitude; showing a 30% reduction in cardiovascular events.
But the study did face criticisms and controversies over methodological issues, including randomization procedures at certain centers, ultimately leading to a retraction of the original paper and a re-analysis.
Participants in the PREDIMED trial were randomly assigned to one of three groups:
- A Mediterranean diet supplemented with extra-virgin olive oil.
- A Mediterranean diet supplemented with mixed nuts (walnuts, almonds, and hazelnuts).
- A control group following a low-fat diet.
Despite the issues it still ends up being an incredibly useful source of data.
In this episode we discuss the findings from PREDIMED, some of the potential limitations, and where it sits among the wider Mediterranean Diet literature.
Note: This is a Premium-exclusive episode, so in order to listen to the full episode you'll need to subscribe to Sigma Nutrition Premium.
Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. As you are currently listening on the public feed of the |
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| 1:00.7 | from these podcast episodes. So without further ado, please enjoy this preview of today's episode. Hello and welcome to Sigma Nutrition Radio. My name is Danny Lennon, and of course with me is Dr. |
| 1:24.9 | Alan Flanagan. Alan, how are you? I'm very well, sir. Yeah. I'm enjoying the rugby world cup. So fingers crossed for the boys in green. |
| 1:33.7 | Well, by the time people hear this, they may have more future knowledge that we don't currently are working with. |
| 1:38.4 | So they could either be laughing at any predictions of a win or saying, yeah, we were justified. |
| 1:45.1 | But at this current moment, pre-South Africa game, we should say, we have relatively high |
| 1:50.5 | hopes for the rest of the tournament for Ireland. |
| 1:52.5 | We do. |
| 1:53.5 | We do. |
| 1:54.5 | We have high hopes. |
| 1:55.5 | Yeah. |
... |
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