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The Human Upgrade: Biohacking for Longevity & Performance

The Natural Ozempic In Your Gut (Eat THIS To Switch It On) : 1404

The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey

Nutrition, Wellness, Lifestyle, Brain, Biohacking, Education, Fitness, Fasting, Science, Meditation, Self-improvement, Health & Fitness, Hacking, Diet, Fat

4.67.4K Ratings

🗓️ 25 January 2026

⏱️ 24 minutes

🧾️ Download transcript

Summary

Your gut already has its own version of Ozempic, and it’s been doing this job long before injections existed.


In this video, I explain how appetite is actually regulated, why synthetic shortcuts often create new problems over time, and what has quietly shut down the body’s natural satiety signals for so many people.


Once you understand the pathway drugs are trying to imitate, the question stops being “how do I eat less?” and becomes “why was my body blocked from doing this in the first place?”


This is about restoring a system, not overpowering it.



Chapters

0:00 - Introduction: Your Body’s Natural Ozempic

0:53 - Hunger Is a Hormone Problem

5:08 - How to Fix Your Hormone Signals

7:28 - Why Ozempic Often Backfires

10:54 - The Resistant Starch Solution

15:03 - How to Use Resistant Starch

18:12 - Rebuilding Your Gut Environment

19:31 - Lifestyle Support for Gut Health


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• Dave Asprey’s BEYOND Conference: https://beyondconference.com  

• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated 

• Upgrade Collective: https://www.ourupgradecollective.com  

• Upgrade Labs: https://upgradelabs.com  

• 40 Years of Zen: https://40yearsofzen.com 


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Transcript

Click on a timestamp to play from that location

0:00.0

Right now, everyone is obsessed with Ozympic and GLP-1s because they shut off hunger fast so you can lose weight. But most people don't know is that your gut already has its own natural Ozympic. And Big Farmo would rather sell you the drug version than remind you that your body has a switch that does the same job. Ozympic only works because it tries to copy that switch. The drug forces a signal to your brain and says, we're full, stop eating, but your gut can send that signal on its own without a needle, without a prescription, without a bill, and without a lot of side effects. When your natural switch is active, appetite drops on its own, cravings quiet down, and visceral fat stores start burning away the way they're supposed to.

0:38.2

And today I'm going to show you exactly how this natural switch works, why it shuts down

0:41.6

in so many people, and how to turn it on using simple tools to restore the system that

0:46.3

OZembek is trying to hijack. And yes, this is classical biohacking knowledge from the guy who

0:51.1

created the biohacking movement. Part 1. Hunger is not a math problem.

0:55.3

It's a hormone problem.

0:57.1

Before we talk about the fix, we need to talk about the mistake almost everyone makes.

1:01.7

See, most people think the secret to weight loss is eating less or counting calories.

1:05.8

In my quest, it was 100 pounds.

1:07.4

I found out that does not work, as has every person who's ever tried to lose weight

1:12.2

sustainably that way. And trust me, callers in, colors out is one of the biggest myths in the

1:17.8

medical field, and they've been telling us this is how to lose weight, it's not. The system wants

1:23.0

you to think that your body is a simple calculator. If you eat fewer calories and you burn,

1:27.3

the fat should just

1:27.9

melt away. This is why the diet apps track every bite, why meal plans obsess over numbers,

1:32.8

why you feel guilty every time you go over your limit, even though you don't really even

1:37.0

know how many colors are in that cookie. It's just a guess. When you overeat, you blame yourself

1:41.6

for not having enough discipline. You start to think hunger is a mindset problem, something you should be able to outthink or outwork if you just try harder. This was my life for years when I weighed 300 pounds. I went to the gym 90 minutes today, six days a week. I was constantly starving, so hungry. I feel that gnawing feeling. It just doesn't work. And a few people lose weight for a short

2:02.2

period of time and then it comes bouncing back just like it did for me over and over. Because in that

2:06.8

Calder is in, colors out story, quantity matters more than biology. So you keep tightening the rules and

2:11.8

hoping the math is finally going to work. Newsflash. It's not that you're not doing it. It's that it doesn't work. But visceral fat, the hidden fat that builds up deep inside your organs. That's actually a hormone problem rooted in the brain's miscommunication with the gut. And visceral fat is the most dangerous kind of fat. I have low levels of visceral fat for an 18-year-old, and the calendar thinks I'm slightly over 50.

2:35.8

My lab test would tell you I'm younger.

...

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