The Microbiome Reset for Fat Loss, Focus & Food Freedom: Dr. Stephen Gundry
Optimal Protein Podcast with Vanessa Spina
Vanessa Spina
4.5 • 758 Ratings
🗓️ 14 April 2025
⏱️ 71 minutes
🧾️ Download transcript
Summary
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What if the key to a leaner body, a clearer mind, and total food freedom isn’t willpower… but your gut bacteria?
In this powerful episode of The Optimal Protein Podcast, I’m joined by world-renowned physician, author, and gut health pioneer Dr. Steven Gundry to dive into the bold insights from his new book, The Gut-Brain Paradox.
Dr. Gundry reveals how an imbalanced microbiome doesn’t just affect digestion — it can hijack your cravings, dull your focus, and even impact your mood, behavior, and metabolism. But here’s the good news: these changes are reversible. And it starts with a targeted reset.
We explore how gut health connects to everything from depression and addiction to Alzheimer’s and disordered eating — and how a protein-optimized, keto-friendly lifestyle can help restore your gut-brain axis for long-term health, vitality, and leanness.
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🧠 What You’ll Learn in This Episode:
• How your gut microbiome may be controlling your food choices, mental clarity, and body composition
• Why gut dysbiosis and leaky gut are linked to brain fog, anxiety, addiction, and neurodegenerative disease
• The shocking connection between gut bacteria and eating disorders like anorexia and binge-eating
• How ketones act as anti-inflammatory signals to support the gut-brain axis
• How to follow a high-protein, low-carb diet that heals your gut and boosts cognitive function
• What the latest science says about 13 specific gut bacteria linked to depression
• The microbiome’s role in dopamine, serotonin, and personality
• How to reset your microbiome for fat loss, mental sharpness, and food freedom
• Why some herbs may only work because of the microbes they carry
• Practical steps, supplements, and food strategies to transform your inner terrain
🔥 Key Takeaways:
• Gut bacteria are influencing your cravings, thoughts, and even motivation — but you can reprogram them.
• A well-formulated ketogenic diet can reduce inflammation and support a diverse, resilient microbiome.
• Optimizing your gut-brain axis may be the most powerful lever for fat loss, focus, and sustainable health.
📚 Featured Book:
The Gut-Brain Paradox: Improve Your Mood, Clear Brain Fog, and Reverse Disease by Healing Your Microbiome
Visit https://ketone.com/VANESSA for 30% OFF your subscription order PLUS receive a free gift with your second shipment—fun surprises like a free 6-pack, Ketone-IQ merch, and more!
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Transcript
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| 0:00.0 | Welcome to the Optimal Protein Podcast. I'm Vanessa Spina. |
| 0:05.6 | Hello, my friends. Welcome back to the podcast. I'm your host, Vanessa. And I am so excited for |
| 0:11.3 | today's episode because we have the Dr. Gundry joining us today. He just authored a brand new book, |
| 0:19.7 | The Gut Brain Paradox. and it is all about fascinating, |
| 0:24.5 | cutting-edge research on the gut microbiome. In our conversation today, we spend the first |
| 0:30.4 | half really talking about the connection between an optimized gut microbiome and being effortlessly lean what different strains of bacteria in the |
| 0:41.8 | gut make people more lean versus more obese how our gut microbiome affects everything from |
| 0:49.3 | our satiety to our food cravings and food choices and how having an optimized gut microbiome can help us to |
| 0:58.0 | produce our satiety hormones like GLP1 and even postbiotics like urolithin A, which timeline |
| 1:06.0 | mitopure has discovered and created in a capsule form. We talk all about the connection between gut health and mental health in the second half and some fascinating research. |
| 1:20.1 | Again, Dr. Gundry always has absolutely mind-blowing research to share about the best sources of pre and postbiotics and also the effect of ketones |
| 1:32.7 | on uncoupling our mitochondria. The best sources of fiber and the best ways to optimize your gut |
| 1:38.5 | microbiome if you are doing a low carb or keto or even carnivore diet and how you can really optimize your gut to reap all |
| 1:48.3 | other benefits. So I loved our conversation today. Dr. Gundry always shares mind-blowing information, |
| 1:54.4 | including how glyphosate has infiltrated our food system and not just for people who consume glyphosate containing products, |
| 2:05.2 | but even the entire food chain and how it has been affected and how glyphosate was actually |
| 2:11.7 | initially patented as an antibiotic and not as a pesticide. So it basically kills off all the healthy bacteria |
| 2:22.1 | and explains why a lot of depression and anxiety and mental health issues are rampant today. |
| 2:29.9 | So I absolutely love this conversation with Dr. Gundry. I would love to hear any takeaways or |
| 2:35.3 | mind-blowing moments that you had from the episode. As always, please do share them in our podcast |
| 2:40.6 | group, which is the Optimal Protein podcast on Facebook. And I will link that in the show notes for |
| 2:46.9 | you all for anyone who wants to join us there for more conversation on these topics. So |
... |
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