The Mega Trial
Movers and Shakers: a podcast about life with Parkinson's
Podot
4.6 • 1.1K Ratings
🗓️ 29 November 2025
⏱️ 27 minutes
🧾️ Download transcript
Summary
How do you run clinical trials that maximise the efficiency for patients, clinicians and drugs developers? That's the challenge being addressed by world's largest ever clinical trial of Parkinson's medications. To discuss this new, and potentially extremely effective, way of runnings multiple trials simultaneously, the Movers & Shakers are joined at the pub by some of the core team from the project, who answer their questions and consider whether this represents the future of clinical trials.
This special episode is sponsored by Cure Parkinson's.
Presented by Rory Cellan-Jones, Gillian Lacey-Solymar, Mark Mardell, Paul Mayhew-Archer, Sir Nicholas Mostyn and Jeremy Paxman.
Produced and edited by Nick Hilton for Podot.
Sound mixing by Ewan Cameron.
Music by Alex Stobbs.
Hosted on Acast. See acast.com/privacy for more information.
Transcript
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| 0:00.0 | Pod-O |
| 0:02.0 | You're listening to Movers and Shakers, a podcast about living with Parkinson's. |
| 0:10.0 | The show is sponsored by Cure Parkinson's, whose urgent and only goal is to find a cure, |
| 0:15.0 | and funded by Bordwave, a networking community for technology leaders, and a passionate supporter of Cure Parkinson's. |
| 0:23.3 | For more details on the charity's progress around research and its fundraising, please visit |
| 0:27.9 | cureparkinsons.org.uk. |
| 0:35.1 | Hello and welcome to the latest episode of the award-winning Movers and Shakers, the podcast about Living with Parkinson's. |
| 0:42.0 | Yes, a good hurrah all around the table here. |
| 0:44.5 | I'm Rory Kathleen Jones. |
| 0:46.1 | Let's see who else has turned up in the pub? |
| 0:48.3 | Nicholas Mostyn. |
| 0:49.3 | Gillian Nacey Solomar. |
| 0:50.7 | Mark Modell. |
| 0:51.8 | Yet again, Paul Mayhew Archer is off filming his Hollywood biopic, his major production, |
| 0:58.6 | which we're all very excited about and hope to be invited along to the premiere next year. |
| 1:03.8 | But this week's episode is devoted to something big in the world of clinical drugs trials. |
| 1:09.3 | In fact, the claim is that it's the biggest Parkinson's drug trial ever, funded to the tune of 26 million pounds. |
| 1:16.2 | The big idea is that the same group of participants can test several drugs in succession. |
| 1:20.9 | When one fails, moving on to another, it's what's known as a multi-arm, multi-stage trial. |
| 1:26.3 | The hope is that by building a platform to test multiple |
| 1:28.6 | drugs, results can be delivered more quickly and efficiently than single drug trials. |
| 1:34.3 | Now, the trial whose name I've deliberately left out until now, because it's the EJS Act PD trial, |
... |
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