The key to a better malaria vaccine | Faith Osier

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4.1 • 11.9K Ratings

🗓️ 16 October 2018

⏱️ 7 minutes

🔗️ Recording | iTunes | RSS

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Summary

The malaria vaccine was invented more than a century ago -- yet each year, hundreds of thousands of people still die from the disease. How can we improve this vital vaccine? In this informative talk, immunologist and TED Fellow Faith Osier shows how she's combining cutting-edge technology with century-old insights in the hopes of creating a new vaccine that eradicates malaria once and for all.

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Transcript

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0:00.0	This TED Talk features infectious disease doctor Faith Oseer recorded live at TED 2018.
0:07.0	There are 200 million clinical cases of falciparum malaria in Africa every year, resulting in half a million deaths.
0:21.6	I would like to talk to you about malaria vaccines.
0:26.0	The ones that we have made to date are simply not good enough.
0:32.5	Why?
0:33.7	We've been working at it for a hundred plus years.
0:38.2	When we started, technology was limited.
0:42.5	We could see just a tiny fraction of what the parasite really looked like.
0:49.9	Today, we are awash with technology, advanced imaging and omics platforms,
0:57.4	genomics, transcriptomics, proteomics.
1:02.1	These tools have given us a clearer view
1:06.0	of just how complex the parasite really is. However, in spite of this, our approach to vaccine design
1:15.6	has remained pretty rudimentary.
1:19.6	To make a good vaccine, we must go back to basics
1:23.6	to understand how our bodies handle this complexity.
1:29.3	People who are frequently infected with malaria learn to deal with it.
1:35.3	They get the infection, but they don't get ill.
1:39.3	The recipe is encoded in antibodies.
1:43.3	My team went back to our complex parasite The recipe is encoded in antibodies.
1:47.7	My team went back to our complex parasite,
1:52.9	probed it with samples from Africans who had overcome malaria to answer the question.
1:55.1	What does a successful antibody response look like?
	...

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