I'm Lester Holt. Tonight on Dadeline, a dramatic new twist in the case of a doctor, his wife, and the mysterious Anne to her life.

Her screams on that call were so raw and so real. I can't believe I'm losing Leslie.

He walked into the bathroom and he found her on the floor.

You sort of thought, gosh, what a terrible accident. She slipped in the shower.

Why is there blood on this wall? Why is there blood on these window shades at the headboard?

There's no way she fell in here and died. I said it's a homicide. Leslie was murdered.

I thought this can't be happening. How could this man be investigated for his wife's death?

You have a doctor. A very, very likable guy who brings babies into the world.

My entire family is standing behind him. Do you think we'd be with him if we thought he was guilty?

This is about standing up for Leslie. She didn't deserve this.

Here's Andrea Canning with the house on Shallamarway.

In a quiet suburban town outside of Syracuse, New York, there's a street called Shallamarway.

A winding cul-de-sac lined with well-adorned mansions, swimming pools, and tennis courts.

Take this final turn and there behind the trees lies one of the street's crown jewels.

An 8,000 square foot home owned by a couple who seemed to have it all.

A close family, wealth, prestige.

They were very involved in the community. Both of them spent their lives giving back.

Life was good here. That is until the morning of September 17, 2012.

It was just before 8.30 a.m. Dr. Robert Newlander, an OBGYN, had returned from a jog to discover his wife Leslie on the floor of the bathroom shower.

He yelled to his 23-year-old daughter, Jenna, to call for help.

My mother, I don't know if she's breathing, but she's laying on the ground in the shower.

So she unconscious? I don't know. I don't know. I don't know. I don't know.

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