The Food and Drug Administration
Let's Know Things
Colin Wright
4.8 • 593 Ratings
🗓️ 22 June 2021
⏱️ 30 minutes
🧾️ Download transcript
Summary
This week we talk about smallpox, the FDA, and Aducanumab.
We also discuss Biogen, regulatory capture, and the Food, Drug, and Cosmetic Act.
This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit letsknowthings.substack.com/subscribe
Transcript
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| 0:00.0 | In 1796, the English medical doctor and scientist Edward Edward Jenner, discovered the necessary components |
| 0:24.3 | and theories behind and developed a version of a smallpox vaccine, which was a revolutionary |
| 0:31.7 | concept at the time, predicated on old folk knowledge, and an observation that milkmaids who came down with a weaker |
| 0:40.5 | version of the disease called cowpox would tend not to catch the more serious and at times |
| 0:47.8 | quite deadly smallpox. He subsequently formalized the process of exposing patients to dead or weakened versions of the disease, |
| 0:59.8 | which gave their immune systems a chance to become familiar with it and build up immune defenses |
| 1:06.3 | that then, when exposed to a full dose of smallpox later, would be primed to protect the owners of those |
| 1:14.3 | immune systems from the worst effects of the disease. This is the same general concept that |
| 1:22.1 | many modern vaccines utilize. And again, at the time, it was quite an important innovation, but also an |
| 1:30.6 | innovation that was almost immediately exploited by criminals hoping to take advantage of the |
| 1:36.8 | popularity of this vaccine. Existing snake oil salesmen pivoted their product promises to claim that their miracle oils cured and |
| 1:47.3 | protected users from smallpox as well. But new fraudsters also emerged, claiming to provide |
| 1:54.3 | their customers with legit, weakened smallpox components, when in reality they were providing something else entirely. |
| 2:04.1 | Usually something harmless, but something that would not offer the promised and desired protections, |
| 2:12.1 | which could then later lead to harm because those receiving these fake treatments would think they were protected |
| 2:20.8 | and behave accordingly. The importance of this vaccine in the still new United States was paramount, |
| 2:30.2 | as like most other places on the planet at that point in time, they were suffering through |
| 2:35.7 | a smallpox pandemic that killed a whole lot of people, and which left those who survived, |
| 2:42.1 | seriously scarred, and at times permanently injured or handicapped. |
| 2:46.5 | And being a new nation, the government could not afford to be hobbled while the rest of the world |
| 2:53.3 | moved forward benefiting from this vaccine. |
| 2:57.6 | This need to keep up led to the Vaccine Act of 1813, the first ever United States federal law |
... |
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