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The Caffeine Plot Twist (over 400 mg was healthier than 0 mg!?)

More Plates More Dates

More Plates More Dates

Health & Fitness, Education, Science, Self-improvement

4.9 β€’ 806 Ratings

πŸ—“οΈ 6 February 2026

⏱️ 19 minutes

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Summary

The newest literature on Caffeine dose and its link to multiple cardiometabolic disease risk reduction (from my conversation with Rhonda Patrick on the MPMD podcast) β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” πŸ“© My private email list for written articles, exclusive offers, sales & more: https://bit.ly/2mtASGW β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” 🦍 https://gorillamind.com/derek (Innovative Pre-Workout, Nootropic, Performance & Health Supporting Formulations) | code "MPMD" for 10% off ⚑ https://gorillamindenergy.com/ (Gorilla Mind's Nootropic Infused Energy Drinks) πŸ’‘ https://intelligent.shop/derek (Intelligent Hair Loss Prevention, Fragrance & Skin Care) | code "MPMD" for 10% off βš•οΈ Marek Health - My Preventive Medicine & HRT Platform: https://bit.ly/373k791 πŸ§ͺ Rigorous Bloodwork Analysis: https://bit.ly/2wI3k9J | code "MPMD" for 10% off 🧴 The Best Hair Loss Prevention Shampoo: https://bit.ly/3pXu5UB | code "MPMD" for 10% off 🧴 Intelligent Minoxidil - The Most Effective Product For Hair Growth (Fast-Drying/Non-Oily): https://bit.ly/3owib2i | code "MPMD" for 10% off βš•οΈ Pharma Grade Hair Loss Treatments: https://bit.ly/3fG20t2 πŸ‘• Fitness & Lifestyle Clothing: https://bit.ly/4dmGKqW | code "MPMD" for 15% off β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” Follow Me On β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” Instagram: https://www.instagram.com/moreplatesmoredates/ X: https://x.com/Derek_Fitness Snapchat: https://www.snapchat.com/add/derek-fit TikTok: https://www.tiktok.com/@moreplates Facebook: https://www.facebook.com/moreplates/ β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” Subscribe To The More Plates More Dates Podcast β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” Spotify: https://open.spotify.com/show/4fCcEMCHgEn57wbGqxKniR Apple Podcasts: https://podcasts.apple.com/us/podcast/more-plates-more-dates/id1424766141 β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€”β€” Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

A lot of people don't really think of stimulants as brain supporting, but there's been a lot of

0:06.0

emerging literature on coffee.

0:08.0

I think you were actually the one who tweeted the study about how like upwards of the

0:13.9

equivalent of like 500 to 600 milligrams of caffeine, I think from coffee was, I, showed a greater benefit of health than, like,

0:24.3

the equivalent of 200 to 300 milligrams of, I don't remember the exact caffeine amount.

0:28.0

You could speak to it, but it was pretty surprising for, like, a lot of people think,

0:32.5

oh, if he passes 400 milligram threshold of caffeine equals bad.

0:38.1

I think what a lot of people don't realize is that

0:40.2

recommendation is based on a body weight multiplier of somebody who was

0:45.3

like under 150, an average of like 150 pounds, I think, but that's

0:48.8

neither here nor there. But as far as that coffee literature that you

0:52.2

presented, I would love to hear just what it showed in terms of benefits, attributes, and like trying to disentangle, is it the caffeine or is it the other stuff from the coffee?

1:05.9

It does seem as though there is a bit of a dose response, like going up to like three, even four cups of coffee a day, you have a stronger effect.

1:15.6

Like you're having more benefit from drinking the coffee.

1:20.2

And notably the best or the highest yield of benefit in that study was a group drinking more than what would otherwise be the

1:29.7

highest recommended dose by the FDA, if I recall correctly. Yeah, I mean, so, you know,

1:34.9

people that are drinking three or four cups, four cups of coffee a day, I think that's a little

1:39.3

bit higher, even up to five cups, actually. What would be a typical cup of coffee?

1:44.9

So it's a loaded question because it depends on so many factors, right?

1:50.0

Like if you're making it at home, if you're going to Starbucks, if you're getting

1:53.1

espresso, so I mean, it could be anywhere between 200 milligrams to like 400 milligrams.

1:58.0

Like it really does depend a lot on where you're getting your source, right?

...

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