The Biohacker’s Guide To Sleep, Nicotine, & Weight Loss | Dave Asprey

Culture Apothecary with Alex Clark

Turning Point USA

Health & Fitness

4.8 • 15K Ratings

🗓️ 10 April 2026

⏱️ 66 minutes

🔗️ Recording | iTunes | RSS

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Summary

Struggling to lose weight? It’s not a willpower problem—it’s a biology problem… and yes, it might start with butter in your coffee.

Dave Asprey—the godfather of biohacking—joins me for one of the most unfiltered conversations we’ve had on the show. We get into his 100+ pound weight loss, why most “health” advice is actually keeping you stuck, and the truth about nicotine, peptides, fasting, and the supplement industry.

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Our Guest:

Dave Asprey

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DISCLAIMER: This content is for informational purposes only and is not medical advice. Always talk to a qualified healthcare professional for any health-related questions or decisions.

Transcript

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0:00.0	If somebody feels tired every day, what is the first thing you'd fix?
0:03.2	Your thyroid gland controls how much energy you have.
0:05.4	So you're going to be tired all the time.
0:06.6	Be a low thyroid.
0:24.2	I'm going to be tired all the time. Eat a lot of oxalates for a lot of years. Darkness at night and sunlight in the morning. It is critically important that you sleep in a blacked out room. That alone can shift the needle for longevity. Cold plunging, nicotine, ditching air pods, peptides, urine therapy, fixing circadian rhythm. What is useless? What actually works? Everything you just listed works if you do it right.
0:29.8	Even urine therapy? You know, I did it this morning. I'm kidding.
0:32.7	Okay. Today I learned if you're struggling losing weight, you don't need more willpower, you just need butter in your coffee.
1:02.2	To controversial takes on nicotine peptides in the whole supplement industry, this episode
1:06.9	is a full-blown interrogation of what actually works when it comes to biohacking and what's a
1:11.4	total scam. According to the man who has literally tried it all, Dave Asprey is a longevity expert,
1:18.0	four-time New York Times bestselling author, and the founder of Danger Coffee, the bulletproof
1:22.4	diet in the entire biohacking movement. After losing over 100 pounds and transforming his own health,
1:28.7	he spent decades helping millions optimize their bodies and their brains. He's the host of the
1:34.0	Human Upgrade podcast and lead some of the most cutting-edge ventures in health and performance.
1:38.8	Watch today's episode on YouTube by subscribing to Real Alex Clark or on Spotify by searching
1:43.6	culture apothecary.
1:44.6	For the ladies listening, join the Kewservatives Facebook group to meet other like-minded women who love this show and continued the discussion.
1:51.6	If you're new, the name of this show came to me in a dream. No, it came to me because we're in a culture war in this country.
2:00.0	And I believe that taking back our health is the key to not only winning, but true freedom.
2:05.1	Our culture needs natural remedies of healing, hence the name, culture apothecary.
2:09.6	So that's where every guest brings their own remedy to heal a sick culture, physically, emotionally, or spiritually.
2:16.2	Pause before we get started.
	...

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