Hey all, you are listening to the real-life pharmacology podcast, and thanks so much for tuning in.

Today I'm going to cover tetracycline antibiotics. I would say, you know, in comparison to something like a penicillin

antibiotic, like a moxacicillin, tetracycline antibiotics are probably used a little less frequently than that.

However, doxaclycline of the tetracyclings is probably the one I see most.

So some examples, doxaclycline, brand name Vibromycin, tetracycline, minasin,

and Demeckla cycling is another tetracycline, Minascycling, brand name Minnesin, and Demecla cycling is another tetracycline

antibiotic, which kind of has a unique potential use that I'll cover here. Mechanistically,

how do these drugs work? Well, in their antibiotic activity, they bind to the 30s ribosomal subunit.

And ultimately, what that binding does is it inhibits the bacteria from producing necessary

proteins for them to continue living as well as proliferating.

So 30s, ribosoma subunit, is where these drugs primarily bind and the activity that they work on.

Fantastic test question I've definitely come across in my career in pharmacology.

Now, with the mechanism and helping to obviously kill bacteria treat infections,

there are certain infections that these drugs tend to treat or have more

activity against. And one that I classically see in my area is Lyme's disease and doxycycline is the

drug of choice for that infection there.

Other conditions, disease states, you might see doxycycline used as an alternative

in pneumonia, for example.

You may see it used for other skin and soft tissue infections.

I also remember kind of throughout school,

doxycycline kind of being an alternative

for lots of different unique infections

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