All right, welcome back to the Sensible Medicine Podcast. I'm once again joined by my friends and colleagues. Dr. Adam Cifu from University of Chicago, John Mandrola, cardiologist Louisville, Kentucky.

Gentlemen, it's a pleasure to see you back. It's a pleasure to see you back here on the Sensible Medicine podcast. We've got a great lineup in store for the listeners. We're going to talk about testosterone, which is a substance that all three of us use exogenously.

No, it's a substance that will be the talk of the topic and when people should use testosterone or not.

We're going to talk about Mike Joyner, who's suspended for the Mayo Clinic for controversial comments in the New York Times.

And we're going to talk about the big question.

Should scientists debate? Dr. Peter

Hotes has been called out by Joe Rogan to debate. Should scientists debate, when should they

debate? What are the rules around that? All right. Let's kick it off. Testosterone. Adam,

you wrote this week in sensible medicine about testosterone. Tell us what's the talk of the town.

Why are we talking about testosterone?

So there was an article last week in the England Journal that got a lot of press, which was looking at whether testosterone is basically safe in older men.

And to sort of pull back on the topic, you know, a low

androgen states is something real. There are men who have very low androgen levels because

testicular problems or problems with their pituitary or hypothalamus, and those people need to be

treated. And then there's this group of men who have been treated for the last 10, 15 years with

testosterone for what seemed to be really low normal testosterone levels, no clear reason

that their testosterone is low, but the idea that, well, you know,

maybe treating them will make them feel better because testosterone, we think, helps a lot of things.

It makes people more energetic, gives them more muscle mass, makes them happier.

And, you know, there's been a debate about whether that's appropriate.

And part of the debate has been, well, is it safe to give someone who's got fairly normal testosterone levels extra testosterone?

And there are plenty of reasons why it might not be safe.

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