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Science Quickly

Tardigrade Protein Protects DNA from Chemical Attack

Science Quickly

Scientific American

Science

4.41.4K Ratings

🗓️ 16 October 2019

⏱️ 3 minutes

🧾️ Download transcript

Summary

The Dsup protein protects DNA under conditions that create caustic free radical chemicals. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

This is a passenger announcement. You can now book your train on Uber and get 10% back in credits to spend on Uber eats.

0:11.0

So you can order your own fries instead of eating everyone else's.

0:15.0

Trains, now on Uber. T's and C's apply. Check the Uber app. This is

0:29.0

Scientific American 60 Second Science. I'm Suzanne Bard. Tartagrades are some of nature's toughest animals.

0:33.2

Also known as water bears, the tiny creatures can withstand extreme conditions,

0:38.4

like boiling hot temperatures, long periods of dehydration, and even oxygen deprivation.

0:45.0

One of the really cool things about tardigrades is that you can shoot them in out of space and they can survive the vacuum and radiation of low-Earth orbit.

0:53.0

University of California San Diego biochemist Jim Cardonaga.

0:58.0

Of course, he says tardigrades didn't evolve to endure the perils of space travel.

1:02.8

Many tardigrades live in environments that are both wet and dry, like moss.

1:07.2

And when it's wet, they're active, and when it's dry, they can go into a desiccated state.

1:12.2

That's something like a state of

1:13.8

suspended animation. Normally dehydration would make tardigrade DNA

1:18.6

susceptible to damage from chemicals

1:24.0

which form when water molecules split.

1:26.0

They also form when DNA is exposed to radiation.

1:30.0

But Kato Naga suspected that a protein found only in Tardigrades, called D-Sep, might protect their DNA under both conditions.

1:39.0

D-Sepstans for damage suppressor protein.

1:42.0

And the remarkable thing about this D-Sup protein is that when you put it into human cells in the laboratory,

1:49.2

it makes those cells more resistant to x-ray radiation.

1:53.3

Kato Naga's team, led by then undergraduate student, Carolina Chavez,

1:58.2

studied how D-Cep protects DNA and cells.

...

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