4.8 • 3.6K Ratings
🗓️ 29 May 2025
⏱️ 14 minutes
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0:00.0 | We ask a lot of questions about our diet. |
0:03.0 | What's the right way to treat a chronic illness, fight off a virus, lose weight? |
0:09.0 | The problem is we get a lot of different answers. |
0:12.0 | Well, I'm here to help. |
0:14.0 | Welcome to the Nutrition Facts podcast. |
0:16.0 | I'm your host Dr. Michael Greger. |
0:19.0 | It sounds like science fiction. |
0:23.1 | Bacteria and a vial of dirt taken from a mysterious island |
0:26.4 | create a compound that prolongs life. |
0:29.6 | And not just in the traditional medical sense, thanks to advances in modern medicine, |
0:33.6 | we're living longer lives, but we're doing so by lengthening the morbidity phase. |
0:39.3 | In other words, we're living longer but sicker lives. |
0:42.3 | Traditional medical approaches tend to just increase the number of old people in bad health. |
0:47.3 | Ideally, though, we'd extend lifespan by slowing aging. |
0:51.3 | That way, we could delay the onset of deterioration rather than just extend |
0:56.9 | the period of deterioration. That's exactly what this new compound appeared to do. Researchers |
1:03.9 | called it rapamycin, named after the bacteria's home, the mystical Easter Island famed |
1:09.2 | for its rock-carved figures, which is known locally |
1:11.6 | as Rapa Nui. |
1:12.6 | Rapamycin inhibits an enzyme that's come to be known as mTOR, or mechanistic target of rapamycin, |
1:20.6 | a key modulator of aging characterized as a master determinant of lifespan and aging. What does the enzyme mTOR actually |
1:29.9 | do? It's the major regulator of growth in animals. Activation of mTOR drives increases in both |
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