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Nutrition Facts with Dr. Greger

Suppressing mTOR

Nutrition Facts with Dr. Greger

[email protected]

Health & Fitness, Alternative Health, Nutrition

4.83.6K Ratings

🗓️ 29 May 2025

⏱️ 14 minutes

🧾️ Download transcript

Summary

mTOR’s a master determinant of lifespan and the engine of aging.
This episode features audio from:

* The Enzyme mTOR as an Engine of Aging
* Inhibiting mTOR with Rapamycin for Extending Lifespan and Healthspan
* Is Rapamycin a Universal Anti-Aging Drug?

Visit the video pages for all sources and doctor's notes related to this podcast.
 

Transcript

Click on a timestamp to play from that location

0:00.0

We ask a lot of questions about our diet.

0:03.0

What's the right way to treat a chronic illness, fight off a virus, lose weight?

0:09.0

The problem is we get a lot of different answers.

0:12.0

Well, I'm here to help.

0:14.0

Welcome to the Nutrition Facts podcast.

0:16.0

I'm your host Dr. Michael Greger.

0:19.0

It sounds like science fiction.

0:23.1

Bacteria and a vial of dirt taken from a mysterious island

0:26.4

create a compound that prolongs life.

0:29.6

And not just in the traditional medical sense, thanks to advances in modern medicine,

0:33.6

we're living longer lives, but we're doing so by lengthening the morbidity phase.

0:39.3

In other words, we're living longer but sicker lives.

0:42.3

Traditional medical approaches tend to just increase the number of old people in bad health.

0:47.3

Ideally, though, we'd extend lifespan by slowing aging.

0:51.3

That way, we could delay the onset of deterioration rather than just extend

0:56.9

the period of deterioration. That's exactly what this new compound appeared to do. Researchers

1:03.9

called it rapamycin, named after the bacteria's home, the mystical Easter Island famed

1:09.2

for its rock-carved figures, which is known locally

1:11.6

as Rapa Nui.

1:12.6

Rapamycin inhibits an enzyme that's come to be known as mTOR, or mechanistic target of rapamycin,

1:20.6

a key modulator of aging characterized as a master determinant of lifespan and aging. What does the enzyme mTOR actually

1:29.9

do? It's the major regulator of growth in animals. Activation of mTOR drives increases in both

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