Study proves that UPFs cause weight gain…or does it?
Nutrition Diva
Macmillan Holdings, LLC
4.4 • 1.8K Ratings
🗓️ 25 February 2026
⏱️ 12 minutes
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Summary
853. A recent study on ultra-processed foods seems to be yet another nail in the coffin for UPFs. But all is not as it seems.
References
Effect of ultra-processed food consumption on male reproductive and metabolic health
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Transcript
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| 0:00.0 | If ultra-processed foods really drive weight gain, then giving people a high-calorie, |
| 0:05.8 | mostly ultra-processed diet should make them gain weight, right? |
| 0:10.4 | And at a glance, this recent study seems to show exactly that, |
| 0:15.3 | except that's not really what happened. |
| 0:19.1 | Now, I may just be a stickler for details, but let me explain why I think |
| 0:23.6 | it's so important to get the details right. |
| 0:33.0 | Hello, this is Monica Reinagle, and you are listening to the Nutrition Diva Podcast, a show where we take a closer look at nutrition news, research, and trends to help you make more informed decisions about what you eat. |
| 0:45.8 | A recent study of ultra-processed foods seems to be yet another nail in the coffin for so-called UPFs. Media outlets generally presented it as more evidence |
| 0:58.6 | that UPFs drive weight gain and have other harmful effects on things like your cholesterol |
| 1:04.4 | and your blood pressure. And that, of course, fits perfectly into the prevailing wisdom about |
| 1:10.6 | UPFs as the root of all evils. The actual |
| 1:15.1 | findings, however, are a little less tidy and a whole lot more interesting. Now, the design of |
| 1:23.1 | this study is a little complicated, but in order to understand the larger point that I want to make |
| 1:28.1 | here, you really need to understand the setup. So here goes. First of all, the subjects were all |
| 1:35.2 | healthy males between the ages of 20 and 35. This is actually pretty typical for university-based |
| 1:43.8 | research labs, because universities tend to have a lot of healthy young men lying around. |
| 1:49.3 | But, obviously, this sample is hardly representative of the general population. |
| 1:56.0 | In any case, these subjects were divided into two main groups. |
| 2:02.2 | The young men in the first group were provided with meals that contained enough calories to maintain their current weight. |
| 2:08.3 | The fellows in the second group were given meals that provided about 500 extra calories per day. |
| 2:16.0 | So all other things being equal, we'd expect those guys to gain around a pound a |
| 2:21.7 | week. They then tested two different diets in each of those groups. One diet was very high in |
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