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Optimal Protein Podcast with Vanessa Spina

Stop Training Fasted? Protein Timing That Boosts Fat Loss in Women — Dr. Katie Hirsch

Optimal Protein Podcast with Vanessa Spina

Vanessa Spina

Nutrition, Fitness, Health & Fitness

4.6795 Ratings

🗓️ 23 February 2026

⏱️ 71 minutes

🧾️ Download transcript

Summary

Fasted training is one of the most persistent fat-loss myths—and in this episode, Dr. Katie Hirsch breaks down what actually matters for women: training quality, muscle preservation, and metabolic health.

We unpack why "burning more fat during a workout" is often the wrong target, and how a small amount of protein (or EAAs) before training can change perceived exertion, improve workout output, and potentially increase post-workout energy expenditure—especially in women who are prone to under-fueling.

We also dive into muscle quality (not just muscle size), why it matters for insulin sensitivity and body composition, and what changes in peri/post-menopause can mean for amino acid delivery to muscle—and how to train and eat to stay lean, strong, and metabolically resilient.

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Episode Topics Covered

  • Fasted vs. fed training for fat loss

  • Protein vs. carbs pre-workout

  • Energy availability and women's physiology

  • Essential amino acids + HIIT

  • Muscle turnover, energy expenditure, and fat oxidation

  • Protein timing, dosing, and distribution

  • Muscle quality (echo intensity), intramuscular fat, and metabolic health

  • Adiposity spillover, visceral fat, and muscle infiltration

  • Perimenopause/postmenopause, estrogen, vascular function, and anabolic resistance

  • Simple strategies for sustainable body recomposition

Dr. Katie Hirsch is an exercise physiologist and sports nutrition researcher focused on protein metabolism, body composition, energy expenditure, HIIT, muscle quality, and female-specific physiology, including changes across perimenopause and postmenopause.

(As mentioned in the episode: she's wrapping up publications on improved methods to characterize hormone profiles and exploring new ways to use bioelectrical impedance outcomes like phase angle to better capture muscle quality and related physiology.)

Protein-Sparing Modified Fasting Library (Coming Soon)

Vanessa shares her behind-the-scenes system built from the approach she used to lose 14+ lbs of body fat while preserving lean mass.

Join the waitlist: Sign up HERE to be the first to know when it has been released!

👉 Subscribe, rate, and review the Optimal Protein Podcast to support the show and help bring you more evidence-based conversations on fat loss, protein, and muscle-centric nutrition.

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The content provided in this podcast is for informational purposes only and should not be construed as medical advice. Consult with a healthcare professional before making significant changes to your diet or exercise regimen.

Transcript

Click on a timestamp to play from that location

0:00.0

Welcome to the optimal protein podcast. I'm Vanessa Spina. Hello, my friends. Welcome

0:06.6

back to the optimal protein podcast. I'm your host Vanessa. I am so excited for today's

0:13.2

episode because we have Dr. Katie Hirsch joining us. And I have been looking forward to

0:19.4

interviewing her for a very long time and I was so excited to

0:24.8

have her on the podcast today. Dr. Hirsch is an exercise physiologist and sports nutrition

0:31.2

researcher whose work focuses on protein metabolism, body composition, energy expenditure,

0:37.4

and female specificspecific physiology.

0:40.5

Now, we really got to do a deep dive today into one of the most persistent myths in fitness culture

0:47.2

that fasted training is superior for fat burning. We really get to unpack whether or not

0:53.6

fasted training truly enhances fat loss,

0:57.3

how consuming protein before exercise may have different effects on women in terms of actually

1:03.8

increasing the total energy expenditure and fat utilization, the role of energy availability

1:10.3

in women's metabolic health, why underfueling

1:14.2

around exercise may actually impair fat loss rather than accelerate it. We also get to talk about

1:20.5

protein, timing, and distribution, and how it influences muscle preservation, her research on

1:27.4

hit exercise, and muscle quality, and what we can do

1:31.9

to enhance our muscle quality. Finally, we discuss her research in Perry and Postmenopausal

1:38.1

women, including practical strategies to enhance body composition during hormonal transitions and why amino acid delivery

1:46.5

to muscle becomes increasingly important as we mature. Today's episode truly is a masterclass in

1:53.9

body recomposition, fat loss strategies, and protein timing with one of the world's leading young researchers in this space.

2:03.8

I was so excited to have Dr. Hirsch on the podcast today, and she really provided a lot of

2:09.5

specific actionable information, so I know you're going to get a ton from today's episode.

...

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