When you're losing weight or you're fasting, insulin levels drop, glucose levels drop,

leptin levels drop, and all of those things contribute collectively to the activation of neurons

that would drive feeding behavior.

The encouraging thing about the brain as a target is it seems to have the ability to promote

bucosloring without causing hypoglycemia and without causing weight gain, which is another

common consequence of insulin-based therapy.

There's no law that says that rising leptin levels are going to trump the motivational value,

the hedonic value of a highly palatable diet, especially if the food is right there kind of

staring you in the face.

Okay. Hello and welcome. I am Danny Len and you are listening to Sigma Nutrition Radio, the podcast that aims to bring you insightful discussions with the world's best active researchers, medical professionals and coaches so that you can take

their insights and apply what parts are relevant to you. Today, we're here at episode 89, and I can

honestly say that I'm truly honored to be talking to Dr. Michael

Schwartz in a few moments' time. Dr. Schwartz is one of the eminent obesity researchers in

the world. He's actually the director of the Diabetes and Obesity Center of Excellence at the

University of Washington. You may have heard Stefan

Guinei mentioned him back in episode 68 as Dr. Schwartz was Stefan Guine's mentor at UW. So when we're

talking about Dr. Schwartz's research, and I'm going to let him dive into it in a bit more

detail in a moment, but really it focuses on the hypothalmic and neuroendic control of energy balance

and glucose metabolism and on the central nervous system mechanisms involved in obesity, insulin

resistance, and diabetes. So we're going to dive into a lot of cool

stuff in that area. Now, the show notes to this episode are going to be at sigamilutrition.com

slash episode 8-9. And if you go there, you can get access to the usual show notes. But also,

...