SNR #195: Brendan Egan, PhD - Exogenous Ketone Supplementation

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 4 September 2017

⏱️ 47 minutes

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Summary

Brendan holds a position as Senior Lecturer in Sport and Exercise Physiology in the School of Health and Human Performance at Dublin City University. His current research investigates the molecular regulation of skeletal muscle function and adaptation across the life course, with special interest in the synergy between nutrition and exercise interventions to optimise performance in athletes and elderly. He received his BSc Sport and Exercise Science from the University of Limerick in 2003, MSc Sport and Exercise Nutrition from Loughborough University in 2004, and PhD from Dublin City University in 2008, before completing two years of post-doctoral training with Prof. Juleen Zierath’s Integrative Physiology group at the Karolinska Institute, Sweden. His doctoral studies focussed on skeletal muscle adaptation to exercise, and in particular the continuity between acute molecular responses to individual bouts of exercise and adaptations induced by exercise training, whereas his post-doctoral training utilised animal models and in vitro cell systems to investigate the transcriptional regulation of skeletal muscle development and mechanisms of insulin resistance. He joined the faculty in the School of Public Health, Physiotherapy, and Sport Science at University College Dublin in 2011, where he spent five years, and retains a position as Visiting Associate Professor. On the sporting front, he has played inter-county Gaelic football with Sligo since 2003, and consults as a performance nutritionist to elite team sport athletes.

Transcript

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0:00.0	So they are quite distinct metabolic states and in fact I would go so far as to say that we shouldn't really be conflating the idea of the ketogenic state with the exogenous
0:21.5	ketone supplemented state. And the work that's been done in other fields, whether it's
0:27.7	in terms of potent supplementation and recovery, whether it's in terms of carbohydrate ingestion
0:31.6	during exercise, you could argue that a lot of those similar studies need to be done with ketones
0:36.1	if we're going to get exogenous ketones if we're going to get an answer as to what the benefits are.
0:41.3	Are we talking about glycogen sparing?
0:42.3	Are we talking about glycogen impairing?
0:44.3	And I think that's a good way of thinking about it.
0:46.3	And the answer is we don't know. Hello and welcome to episode 195 of Sigma Nutrition Radio. My name is Danny Lennon. And for those of you who are
1:15.9	returning as loyal listeners, thank you so much again for tuning into the show. And welcome to any new
1:21.5	listeners we have to the podcast. I hope you enjoy this and find value in going back and searching
1:26.5	previous episodes as well. Today, I'm
1:29.5	absolutely delighted to be rejoined on the podcast by Dr. Brendan Egan of Dublin City University,
1:35.4	who was on the show a couple of years ago looking at the areas of sarcopenia, anabolic
1:41.2	resistance, and related research in that area.
1:44.7	And in today's episode, we're going to turn our attention to another area that's caught
1:49.5	the imagination of a lot of people in research over the past couple of years.
1:52.9	And that's looking at exogenous ketone supplementation, particularly in the context
1:57.6	of athletic performance and recovery.
2:00.9	So Brendan has been doing some fascinating work for many years now with his research,
2:05.5	mainly focusing around molecular regulation of skeletal muscle function and adaptation,
2:11.0	with a lot of that based on nutrition and exercise interventions
	...

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