SNR #129: Chris Masterjohn, PhD - Glycation, Oxidative Stress & The Protective Effects of Glucose and Insulin

Sigma Nutrition Radio

Danny Lennon

Sigma, Dietetics, Evidencebased, Nutrition, Training, Health & Fitness, Science, Diet, Fitness, Evidence, Bodybuilding, Health

4.8 • 626 Ratings

🗓️ 5 July 2016

⏱️ 71 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode 129: Chris Masterjohn, PhD discusses the role of carbohydrates and insulin in endogenous antioxidant systems, oxidative stress and misconceptions on glycation.

Chris is currently Assistant Professor of Health and Nutrition Sciences at Brooklyn College, part of the City University of New York. He has a PhD in Nutritional Sciences from the University of Connecticut.

His dissertation was about the role of glutathione, an antioxidant and detoxifying molecule that we make within our own bodies from dietary protein, in preventing the accumulation of methylglyoxal, a potentially toxic compound formed in small amounts during energy metabolism that is believed to play a role in diabetes and other degenerative diseases.

He writes detailed nutritional science articles on his blog The Daily Lipid and hosts a podcast by the same name.

In this episode we discuss:

Why it's important people don't fall into the trap of demonizing sugar in the same way they argue other have done to dietary fat in the past.
The realtionship between oxidative stress, glycation and diet.
The role of glucose and insulin in our bodies' antioxidant systems
Why restricting carbohydrates out of fear they increase glycation is erroneous

Transcript

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0:00.0	That whole suite of responses is all based on the mitochondria experienced some increased
0:11.3	demand.
0:12.1	What can it do to survive the demands that it expects in the future?
0:17.8	And if that mitochondrian says, well, I don't think I can handle this workload, but I'll do it
0:23.7	anyway, then that is where you get oxidative damage because you have this constant load of reactive
0:29.6	oxygen species that can't be dealt with. That's only true because they're communicating that cell
0:35.8	signaling that relieves the pressure on them.
0:38.1	If they didn't communicate that, then the alternative is a total disaster because what you
0:44.5	would have is widespread oxidative damage of all the cellular components. Hello and welcome to Sigma Nutrition Radio, the podcast that brings you evidence-based discussions with the world's leading researchers in fields related to nutrition and health.
1:19.7	I am your host, Danny Lennon, and you are listening to episode 129.
1:26.5	And on today's podcast, I'm delighted to have Chris Masterjohn on to discuss
1:32.3	glycation and oxidative stress, which were topics central to Chris's doctoral research when he was
1:39.3	completing his PhD in Nutritional Sciences at the University of Connecticut. And he's one of the most well-read
1:47.0	guys that I've ever came across in this particular area. And his depth of knowledge in this
1:52.7	particular area is remarkable, as well as another number of different areas within nutrition as well.
1:59.9	And to be honest, Chris is probably one of the most intelligent guys.
2:04.0	I've had the pleasure to chat to.
2:06.0	And I've been a massive fan of his work for many, many years now.
2:10.4	And so I'm just really delighted to have him on the show today.
2:14.1	While this will be quite an in-depth podcast, so we're going to get dig right into some details, get down into some pretty nerdy stuff.
2:23.2	I think there are still some massive takeaways for even those you are not as interested in the nitty gritty details that we might get into.
2:32.1	There are some huge takeaways, particularly,
	...

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