SNP20: The Cumulative Exposure Model of LDL-C & Heart Disease
Sigma Nutrition Radio
Danny Lennon
4.8 • 633 Ratings
🗓️ 22 August 2023
⏱️ 13 minutes
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Summary
This is a Premium-exclusive episode, so here you'll only hear a preview. In order to listen to the full episode you'll need to subscribe to Sigma Nutrition Premium.
About This Episode:
It has been clearly demonstrated that elevated LDL-cholesterol (LDL-C), or perhaps more specifically pro-atherogenic lipoproteins, is causal in atherosclerosis development in humans.
One crucial concept within this is that the risk relates not only to the magnitude of elevated LDL-C, but the duration of exposure. Thus, the role of LDL-C in driving atherosclerosis is referred to as a "cumulative, integrated exposure over the lifecourse".
But, what exactly does this mean?
In this episode, Danny discusses the cumulative exposure model of LDL-C in atherosclerosis, the evidence supporting it, and the implications of this for the "debates" that get raised in relation to LDL-C (or apoB-containing lipoproteins) and heart disease.
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Transcript
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| 0:00.0 | Hello and welcome to Sigma Nutrition Radio. As you are currently listening on the public feed of the |
| 0:06.0 | podcast, what you're going to listen to today is a preview of one of our premium exclusive episodes. |
| 0:11.6 | These are episodes that we publish in their entirety on our Sigma Nutrition Premium podcast feed, |
| 0:17.7 | and therefore to listen to that in its entirety, you need to be a Sigma Nutrition |
| 0:21.5 | Premium Subscriber. Being a premium subscriber also gives you a host of other benefits, |
| 0:26.1 | including detailed study notes to our podcast episodes and full episode transcripts, |
| 0:31.8 | as well as other materials that help you get more from your podcast listening. |
| 0:36.7 | So take a listen to this preview today. I hope you |
| 0:39.3 | enjoy it. And if you want to get these extra bonus podcast episodes in their entirety, as well as those |
| 0:44.8 | other benefits, then take a look at Sigma Nutrition Premium, which is linked in the description |
| 0:49.5 | box wherever you're currently listening or over on Sigma Nutrition.com slash premium. See if it's for you, |
| 0:56.3 | maybe give it a try and I think it's really going to enhance how much you learn and retain |
| 1:00.7 | from these podcast episodes. So without further ado, please enjoy this preview of today's episode. Hello and welcome to this episode of Sigma Nutrition Premium. My name is Danny |
| 1:25.2 | Lennon. You're very welcome to the podcast. And today I wanted to discuss |
| 1:30.7 | a topic that has been raised on several of our previous episodes. You've probably heard this phrase |
| 1:36.5 | a number of times, but to go through it in a bit more depth and to really explain some of the |
| 1:41.8 | important aspects of it and why we reference it |
| 1:44.5 | and so often. And that is the concept of the cumulative exposure model of LDL cholesterol |
| 1:51.7 | and heart disease and specifically atherosclerosis development. So of course, |
| 1:57.8 | atherosclerosis is this condition where we have a buildup of these plaques inside the arteries. |
| 2:03.6 | It's typically one that progresses over a long period of time relatively slowly and symptoms as such don't necessarily occur until you have an advanced stage of that. |
| 2:16.6 | In other words, when you get a situation where |
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