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Science Quickly

Skinny Genes Tell Fat to Burn

Science Quickly

Scientific American

Science

4.2639 Ratings

🗓️ 22 May 2020

⏱️ 3 minutes

🧾️ Download transcript

Summary

A gene whose mutated form is associated with cancer in humans turns out to have a role in burning calories over a long evolutionary history. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Understanding the human body is a team effort. That's where the Yachtel group comes in.

0:05.8

Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years.

0:11.0

Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program.

0:19.6

To learn more about Yachtolt, visit yawcult.co.

0:22.7

.jp. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacult.

0:33.5

This is Scientific Americans' 60-second science. I'm Karen Hopkin.

0:38.3

Do you have skinny genes? I'm not talking about the pants you wore in college but can't fit into anymore.

0:45.2

No, skinny G-E-N-E-S genes are factors found in folks who are naturally spelt.

0:51.1

And researchers have just identified one that appears to tell the body's adipose tissue

0:55.3

to burn more fat. We all know these people who can eat whatever they want, but never gain any weight.

1:01.8

Yosef Penninger is a geneticist at the University of British Columbia. He says that individuals who

1:07.1

are effortlessly trim may hold the key to understanding obesity. See, scientists interested

1:12.6

in learning how we control our weight have traditionally focused on the things that make you fat,

1:17.6

like diet or metabolism. But not really studied why people actually stay skinny. So we thought

1:24.6

we just turn around the fields and study genetics of sinness.

1:29.7

Penninger and his colleagues started out by searching a database, maintained by a genome center in

1:34.4

Estonia, for its most slender registrants. And they weeded out people who were listed as having

1:39.9

anorexia or other conditions that alter body fat. Then, they looked for genetic markers that

1:45.4

track with these skinny peats. One gene in particular caught their eye. Al-K, or the gene for

1:51.9

anaplastic lymphoma kinase, is a stretch of DNA whose mutant form has been associated with human

1:57.7

cancers. But its normal function had never been established.

2:01.7

So the scientist made mutant fruit flies and mutant mice.

...

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