SIBO & IBS: The Latest Research & Testing Options with Dr. Mark Pimentel | Ep 181

The Funk'tional Nutrition Podcast

Erin Holt

Mental Health, Health & Fitness, Alternative Health, Nutrition

4.9 • 759 Ratings

🗓️ 16 November 2021

⏱️ 61 minutes

🔗️ Recording | iTunes | RSS

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Summary

We’ve got a special episode for you today. Erin sits down with Dr. Mark Pimentel, researcher, clinician, and cofounder of Gemelli Biotech™, to discuss the latest research on IBS, SIBO, and new testing options for people who have struggled with these conditions. This is definitely a higher level podcast interview, so this episode is great for clinicians, practitioners, anyone who loves to geek out on gut health and research, or anyone who’s been struggling with IBS or SIBO and looking for answers. Erin and Mark discuss leading causes of IBS, the overlap of IBS & SIBO, why patients are often being dismissed in other practices, how the blood tests and breath tests for diagnosing these conditions work, why the treatment strategies are nuanced, and much more. What makes Dr. Mark Pimentel's insights noteworthy is he’s not just a researcher; he’s also a clinician, and it’s the process of taking that information and applying it to humans where we learn so much. This is an episode you’ll want to refer back to - share with someone who could use this information! In this episode: -Why today’s guest is particularly noteworthy [1:08] -Why Mark Pimentel continues his research [8:42] -What is the leading cause of IBS? [10:37] -The value behind the ibs-smart™ blood test [13:32] -Inferring antibody patterns in post-infectious IBS [16:23] -New research that debunks two widely accepted concepts about SIBO [21:41] -The overlap between post-infectious IBS and SIBO [23:26] -New info on PPI (proton pump inhibitor) use and SIBO [27:45] -The potential problem with akkermansia as a probiotic supplement & other single-organism treatments [30:43] -How does Intermittent Fasting or fluid affect the migrating motor complex & should these strategies be considered for IBS? [37:28] -Hydrogen sulfide and the trio-smart® breath test for SIBO [39:18] -How treatment differs for hydrogen-dominant SIBO (SIBO-D), Intestinal Methanogen Overgrowth (IMO) & hydrogen sulfide SIBO (H2S SIBO) [45:25] -Does constipation with H2S occur? [48:55] -The various types of bacteria that produce hydrogen gas [51:02] -The mechanism of action of lovastatin as future treatment for methane in constipation [53:26] -Using prokinetics for low motility [55:35] -Pimentel’s thoughts on the low FODMAP diet [56:56] FOR OUR FULL LIST OF LINKS + RESOURCES, HEAD TO: https://www.erinholthealth.com/funktional-nutrition-podcast/2021/11/16/episode-181-sibo-amp-ibs-the-latest-research-amp-testing-options-with-dr-mark-pimentel

Transcript

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0:00.0	Welcome to the Functional Nutrition Podcast. I'm your host, Erin Holt. I'm a functional
0:07.4	medicine nutritionist with a feisty attitude in over a decade of clinical experience. I work with
0:13.3	women all over the world through my online programs, and I'm also the founder of the Functional
0:18.9	Nutrition Academy, a 12-month practitioner mentorship where I help other nutrition pros level up
0:25.3	with functional medicine methodologies.
0:27.9	I've got a bone to pick with diet culture and the conventional healthcare model
0:31.6	that are both systematically failing so many of us.
0:35.3	Creating a new model is my life's work, and this is what the show's all about.
0:40.4	Please keep in mind this podcast is created for educational purposes only and should never be
0:45.7	used as a replacement for medical diagnosis or treatment. If you like what you hear today,
0:50.9	I'd love for you to subscribe, leave a review in iTunes, share with a friend,
0:55.4	and keep coming back for more. Thanks for joining me. Now let's dive deep.
1:02.2	Okay, wow, do I have a podcast episode for you? When I started this podcast over four years ago,
1:10.0	never did I ever think that I would be sitting down with the Dr. Mark Pimentel?
1:19.0	It's a bit of a surreal moment for me, to be honest with you. I never thought that I would have the privilege to sit down with somebody who I've looked up to, and quite frankly,
1:30.8	every single person in my field has looked up to for a great many years.
1:37.1	Dr. Mark Pimentel is the professor of medicine at Geffen School of Medicine and Cedars-Sinai Medical
1:43.9	Center in L.A., California.
1:47.0	He's very active in research and has served as the principal investigator for a lot of different
1:54.3	clinical studies in the areas of IBS, of SIBO, the connection between our gut flora and disease. He truly is an expert in
2:07.1	his field. One of the reasons that I respect his work so much and look to his work so much
2:12.8	when I am in practice and mentoring my clinicians in the functional nutrition academy
	...

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