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Locked On 49ers - Daily Podcast On The San Francisco 49ers

SHOWDOWN: 49ers Host Cardinals in Clash of NFC West Unbeatens

Locked On 49ers - Daily Podcast On The San Francisco 49ers

Locked On Podcast Network

Bay Area, Bay Area Nfl, Sports Podcast, Football, 49ers Nfl, 49ers Highlights, Podcast, Daily Podcast, 49ers Podcast, 49ers Today, San Francisco, Sports, San Francisco Football, 49ers Football, Bay Area Football, 49ers News, Nfl, 49ers Game, 49ers, San Francisco 49ers, Sourdough Sam, San Francisco Nfl, Niners

4.6989 Ratings

🗓️ 18 September 2025

⏱️ 32 minutes

🧾️ Download transcript

Summary

Will the 49ers' injury woes derail their momentum against a hungry Cardinals squad? San Francisco's quarterback situation hangs in the balance as Brock Purdy battles turf toe, while Arizona grapples with a depleted secondary.

Transcript

Click on a timestamp to play from that location

0:00.0

Mac Jones played well in week two, but according to Kyle Shanahan, there is a chance that Brock Purdy will play against the Cardinals in week three.

0:08.7

And even though the Arizona Cardinals have started two and O, they may have skated absolute defensive disaster with the report out today.

0:16.8

Matchups and a whole lot more on this week's 49ers Cardinals crossover.

0:21.6

Let's get it.

0:27.4

You are locked on NFL crossover, part of the Locked On Podcast Network,

0:33.7

your team every day.

0:38.3

Welcome to another Locked podcast network crossover episode.

0:42.5

Brian Peacock here of Locked on 49ers alongside Alex Clancy of Locked on Cardinals,

0:49.5

getting ready for some week three action,

0:52.3

two unbeatens here in the NFC West. So it's going to be a whole lot of fun. We're going to get into the biggest storyline, some key matchups here, and maybe even some predictions at the end of this show, what we think is going to go down this Sunday as the 49ers hosts, the Cardinals, the 49ers home opener. I do want to thank everybody for joining us, the everydayers, all those 49ers and

1:12.7

Cardinals fans out there.

1:14.0

And of course, hit that subscribe button on YouTube or wherever you are listening to this

1:18.9

podcast.

1:20.0

And a lot of injuries for both of these football teams, some new injuries today.

1:24.0

In fact, when I did the Peacock and Williamson, right here on the

1:29.0

Locked on Podcast Network, subscribe daily, myself. Pick that name up. The entire league.

1:34.6

And we did our picks. We do a six pack on our Wednesday episode. And so earlier Wednesday,

1:42.1

we recorded. And the 49ers were favored by one and a half.

1:45.5

And I'm not going to tell you who I picked. But now with the news of Brock Purdy doing a little

1:50.6

limited practice and Kyle Shanahan says there's a chance that he might still be able to play

1:54.5

in week three. And with some bad injury news for the Arizona Cardinals, that line has actually

1:59.8

moved to two and a half points now. So what's going on over there in Arizona with these cards?

...

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