Welcome back to the Plenary Session podcast. This is the podcast at the intersection of medicine,

oncology, and health policy. We're back with a good episode. Recently, I was recording with Dr. Adam

Sifu and John Mandrola for the Sensible Medicine Feed. I'm going to make that audio available here

because it was such a great conversation. I think you'll like it and because too few people are listening to it over there.

So I also encourage you to subscribe to the Sensible Medicine podcast.

In the second part of this, I'm going to play the audio of a video I made for YouTube about Rochelle Walenski and the lie she told Congress.

And later this week, I'll be back with a lecture on cost of drugs.

You won't want to miss it.

Stay tuned.

Welcome back again to the sensible medicine roundtable discussion.

I'm joined by Professor Adam Seafood from the University of Chicago and Dr. John Mandrola,

cardiologist from Louisville, Kentucky.

Gentlemen, it's great to see you again.

We have a great lineup in store for you. First, we're going to talk about how to interpret studies, particularly when there's residual uncertainty, which there always is.

Next, we're going to talk about seven doses of booster, seven doses of vaccine, I guess five boosters and two bivalent boosters.

It's like I always say, seventh one's the charm.

We're going to talk about that. And then if we have time, we're going to talk about A, B, I, M, and certification, board

certification.

So gentlemen, it's great to see you again.

Why don't we have Adam kick this off?

So this is all about uncertainty and study design.

Whenever you run a study, you get, particularly randomized study, you'll get some point estimate but you also get a

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