Sending datacenters into orbit | E2203
This Week in Startups
Jason Calacanis
4.4 • 1.3K Ratings
🗓️ 3 November 2025
⏱️ 78 minutes
🧾️ Download transcript
Summary
👉 Register here to join the Founder University Japan kickoff! https://luma.com/cm0x90mk
Today’s show:
*Starcloud has started sending AI chips into orbit. So is this where the datacenters the power AI will one day live? And does wifi work in the vacuum of space? We’re asking the TOUGH questions.
PLUS Jason and Alex are doing a deep dive on all this week’s OpenAI news. Will they ever be able to pay back all these GPU purchases? What happens to the wider economy on the off chance they don’t thrive? And what’s with these rumors that ChatGPT has stopped giving medical or legal advice?
All that and a look at TrustMRR (and why Jason advises you not to publicly share your Stripe), why Jason thinks Netflix should buy CNN, our hosts favorite Nazi hunter movies, and MORE.
Timestamps:
(0:00) Would you trust an LLM with your health?
(2:08) Jason is bringing Founder U to The Kingdom AND Japan, so he’s streaming in today live from Riyadh
(4:20) Jason’s guide to mastering international travel. (Shoutout to Whoop)
(5:05) Are the big AI companies going TOO HARD on GPUs? And does this matter?
(11:30) Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST
(14:53) What happens to the wider economy if ChatGPT FAILS? Who gets hit by the “contagion”?
(18:22) Jason’s more likely scenario: What if ChatGPT becomes just one player in a larger market?
(21:22) Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.
(23:57) ChatGPT can still give you general health and legal advice… just not a full diagnosis
(31:57) Nexos.ai Stop Shadow AI in its tracks with the unified platform for secure AI adoption and productivity. Try it with a free 14-day trial at https://nexos.ai/twist.
(33:09) TrustMRR and startups sharing their Stripe data… Why Jason says total transparency might be too much
(38:35) We’re really sending datacenters to space! Starcloud made it happen.
(41:02) Does wifi work in space? A TWiST investigation…
(47:01) Checking in with Polymarkets on the NYC mayoral election and the government shutdown
(53:09) Legal AI startup Legora (from Sweden) is now a unicorn… why this niche is growing so fast
(58:14) Netflix wants to buy WBD… Here’s why our hosts think they should keep CNN.
(1:07:58) BUT WE DIGRESS: Lon and Jason’s favorite Nazi hunter movies
(1:10:25) Founder Q’s! The best way to track runway and burn rate for early stage companies.
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Squarespace - Use offer code TWIST to save 10% off your first purchase of a website or domain at https://www.Squarespace.com/TWIST
Pilot - Visit https://www.pilot.com/twist and get $1,200 off your first year.
Nexos.ai Stop Shadow AI in its tracks with the unified platform for secure AI adoption and productivity. Try it with a free 14-day trial at https://nexos.ai/twist.
Transcript
Click on a timestamp to play from that location
| 0:00.0 | If you told me your health is at risk, here's your choices. |
| 0:04.5 | This one doctor is going to give you, these three doctors are going to give you their best |
| 0:09.3 | advice. |
| 0:10.9 | Or you can pick these three LLMs and you can feed the information, same information |
| 0:15.3 | you give to these three doctors or these three LMs. |
| 0:17.2 | I'm taking the three LLMs. |
| 0:19.3 | That sounds crazy, I know, but I think for almost every case, |
| 0:22.2 | I would do that. What would you do, Alex? I would talk to the physicians because I have a great |
| 0:28.7 | number of them in my geographically local family here, and I hear about what people bring to them |
| 0:34.8 | from LLMs and what kind of advice they're getting, not just Chiant GAPT, but the whole gamut. And I don't think that the app, Jason, the average person's not very smart. So they're not doing great research here. They're not doing good protection. No, I'm saying for you, for you, though. Even with all that, no. Okay. Yeah. And do you think in the coming years it would change? |
| 0:54.9 | Oh, five years from now? |
| 0:56.1 | Oh, God. |
| 0:56.7 | I mean, I'm either going to be in a flying zooks or I'm going to be digging in the ground with sticks. So I'll take the LLMs in five years, yeah. Yeah. So I think it's then it's just a matter of time. We're in agreement. Oh, I think most AI questions is just your time horizon, you know, like, so you know what this sounds like to me? |
| 1:11.1 | It sounds to me? |
| 1:11.1 | It sounds to me like people with credentials are going to start suing the LLMs for giving |
| 1:17.4 | advice without a license. |
| 1:19.5 | This week in startups is brought to you by Nexos. |
| 1:23.2 | Stop Shadow AI in its tracks with the unified platform for secure AI adoption and productivity. |
| 1:30.8 | Try it with a free 14-day trial at nexos.a.i slash twist. Pilot. Focus on your product. Let Pilot |
| 1:38.8 | handle the bookkeeping. Pilot provides the most reliable accounting, CFO, and tax services for startups and small businesses. |
| 1:46.9 | Head to pilot.com slash twist and get $1,200 off your first year. |
| 1:52.4 | And Squarespace. |
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