Selma Blair on Living With MS and Finding Grace in Uncertainty (October 2025)

Making Space with Hoda Kotb

NBC News

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4.9 • 10.2K Ratings

🗓️ 11 March 2026

⏱️ 37 minutes

🔗️ Recording | iTunes | RSS

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Summary

As MS Awareness Month continues, Selma Blair’s story underscores the resilience it takes to keep moving forward while living with multiple sclerosis. Blair, the actress known for "Cruel Intentions," "Legally Blonde" and the "Hellboy" films, has become a leading voice in the MS community since publicly sharing her diagnosis in 2018. In this conversation from October 2025, Blair joins Hoda to discuss her lifelong health struggles, her relationship with her late mother, and the support she has found in her community, including from fellow stars Christina Applegate and Jamie-Lynn Sigler, who are navigating their own MS journeys.

Transcript

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0:00.0	Some stories remind us that true courage is not about avoiding challenges, but it's about facing them with grace, determination, and heart.
0:17.5	Selma Blair's story is one of those. For more than two decades, Selma has captivated audiences on
0:23.2	screen with iconic roles in cruel intentions, legally blonde, and hellboy. She's a devoted mother,
0:29.5	an acclaimed actress, a best-selling author, and a style icon who brings depth and complexity
0:35.3	to everything she does.
0:40.7	But behind the scenes, she's faced a battle so crippling,
0:42.8	it almost caused her to step away.
0:45.2	From the time she was a kid,
0:47.6	Selma dealt with physical ailments,
0:51.5	from losing control over her body to crying at any given moment.
0:55.4	All along, she was told she was just making it up.
1:04.0	In 2018, after 40 years of struggling, Selma was officially diagnosed with multiple sclerosis,
1:10.3	opening up a chapter of healing and advocacy in her life. Through her honesty and unwavering spirit, she's shown the world a new
1:12.3	kind of strength, becoming a voice of hope for millions living with chronic illnesses. In our
1:18.1	conversation, Selma opens up about her journey, how she finds light in the darkness, what
1:23.5	keeps her moving forward, and why she believes vulnerability is its own kind of superpower.
1:29.1	I'm Hoda Koppi. Welcome to my podcast, Making Space.
1:48.2	First of all, I'm so happy to see you.
1:54.5	And I just did, I like to do a little Google situation before we do an interview.
1:56.5	And I just saw a TED talk.
1:56.7	Oh, no. Oh, this is good, though.
1:57.8	This is good, though.
	...

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