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Huberman Lab

Science of Stress, Testosterone & Free Will | Dr. Robert Sapolsky

Huberman Lab

Scicomm Media

Science, Life Sciences, Health & Fitness

4.830.3K Ratings

🗓️ 30 August 2021

⏱️ 91 minutes

🧾️ Download transcript

Summary

In this episode, I interview Dr. Robert Sapolsky, Ph.D., Professor of Biology, Neurology & Neurosurgery at Stanford University. We discuss stress, what defines short-term versus long-term stress, and how stress can be beneficial or detrimental, depending on the context. We also discuss stress mitigation and how our sense of control over stress mitigation techniques, including exercise, determine health outcomes. Dr. Sapolsky explains some of the key effects of the hormone testosterone — how it can amplify pre-existing tendencies for aggression or sexual behavior, but that it does not produce those behaviors per se. He also explains how testosterone impacts our social hierarchies, sense of confidence, and willingness to embrace challenges of different kinds. He also explains how our behaviors and perceptions shape testosterone levels. And we discuss estrogen and the powerful role it plays in brain development, health and longevity. Finally, we discuss free will, what it means to have free will, and if we have any free will, including how knowledge alone might allow us to make better decisions for ourselves and society.  Read the full show notes for this episode at hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman LMNT: https://drinklmnt.com/hubermanlab Waking Up: https://wakingup.com/huberman Momentous: https://livemomentous.com/huberman Timestamps 00:00:00 Introduction: Dr. Robert Sapolsky   00:02:25 Sponsors: AG1, LMNT & Waking Up 00:06:30 Stress: Short & Long-Term, Good & Bad   00:09:11 Valence & Amygdala   00:11:00 Testosterone: Common Myths vs. Actual Truths   00:15:15 Behaviors that Affect Testosterone   00:17:20 Mindsets & Contexts that Affect Testosterone   00:20:28 How Finger Length Ratios Reflect Prenatal Hormone Levels   00:22:30 Aggression: Male-Female, Female-Male, & Female-Female   00:24:05 Testosterone: The Challenge Hypothesis   00:29:20 How Dopamine Impacts Testosterone & Motivation   00:32:32 Estrogen: Improves Brain & Longevity BUT TIMING IS KEY   00:39:40 Are Testosterone & Sperm Counts in Males Really Dropping?   00:42:15 Stress Mitigation & Our Sense of Control   00:51:35 How Best to Buffer Stress   00:57:04 Power of Perception, Choice & Individual Differences   01:00:32 Context-Setting, Prefrontal Cortex & Hierarchy   01:11:20 How Dr. Sapolsky Accomplishes Deep Thinking   01:13:17 Do We Have Free Will?   01:20:50 How to Apply Knowledge & Learning   01:23:44 Robert’s New Book: “Determined: The Science of Life Without Free Will”   01:28:27 Reflections, Support of Podcast, & Supporting Stress Research   Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Welcome to the Uberman Lab podcast where we discuss science and science-based tools for everyday life.

0:09.0

I'm Andrew Uberman and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.

0:15.0

Today I have the pleasure of introducing Dr. Robert Sapolsky. Dr. Sapolsky is a professor of biology and neurosurgery at Stanford University.

0:23.0

His laboratory has worked on a large variety of topics including stress, hormones including testosterone and estrogen,

0:31.0

and how the different members of a given species interact according to factors like hormones, hierarchy within primate troops,

0:39.0

and how things like stress, reproduction, and competition impact behavior.

0:45.0

One of the things that makes Dr. Sapolsky's work so unique is that it combines elements from primatology, including field studies,

0:52.0

with human behavior, in essence, trying to unveil how humans as old world primates are controlled by different elements of our biology as well as our psychology.

1:03.0

Dr. Sapolsky is also a prolific author of popular books such as Wisebres Donket Alcers, the trouble with testosterone, and behave the biology of humans at our best and worst.

1:15.0

During the course of our discussion today, Robert also revealed to me that he is close to completing a new book entitled Determined, The Science of Life Without Free Will,

1:25.0

and indeed we discuss the science of life without free will during this episode.

1:29.0

We also discuss stress and how best to control stress and how stress controls us at both conscious and subconscious levels.

1:38.0

We talk about testosterone and estrogen and hormone replacement therapy and how those impact our mind, our psychology, and our interactions with others.

1:47.0

As with any discussion with Dr. Sapolsky, we learn about scientific mechanisms that make us who we are.

1:53.0

And today we also discuss tools and how we can leverage those scientific mechanisms in order to be better versions of ourselves.

2:00.0

I should mention that unlike most guest interviews on the Huberman Lab podcast, this one had to be carried out remotely due to various constraints.

2:07.0

So you may hear the occasional audio artifact. Please excuse that. We felt that the value of a conversation with Dr. Sapolsky was well worth those minor minor glitches.

2:18.0

And indeed the information that he delivers us is tremendously valuable, interesting, and in many cases actionable as well.

2:25.0

Before we begin, I'd like to emphasize that this podcast is separate from my teaching and research roles at Stanford.

2:31.0

It is however part of my desire and effort to bring zero cost to consumer information about science and science related tools to the general public.

2:39.0

In keeping with that theme, I'd like to thank the sponsors of today's podcast.

2:43.0

Our first sponsor is Athletic Greens. Athletic Greens is an all-in-one vitamin mineral probiotic drink.

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