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BETTER! with Dr. Stephanie Estima | Strength, Body Composition & Perimenopause

Saving Marriages & Bedroom Comebacks: Midlife Women on Testosterone with Shalin Shah

BETTER! with Dr. Stephanie Estima | Strength, Body Composition & Perimenopause

Dr. Stephanie Estima

Intimacy, Menopause, Betterpodcast, Nutrition, Women's Health, Menstruation, Hormones, Optimization, Sex, Fitness, Sleep, Dr. Stephanie, Health & Fitness, Science, Parenting, Motherhood, Health, Self Care, Drstephanie, Mindset, Alternative Health, Self Love

4.8613 Ratings

🗓️ 12 January 2026

⏱️ 66 minutes

🧾️ Download transcript

Summary

Your husband can get testosterone therapy by sneezing in his doctor's general direction, but you're told it's "just aging" and here's an SSRI. Shalin Shah is here to blow up every myth about testosterone and women's health—because spoiler alert: that brain fog, disappearing muscle, and stubborn belly fat might not be a "you" problem, it's a hormone problem. Watch the full episode at https://youtu.be/7Kf5orCNH-g

Transcript

Click on a timestamp to play from that location

0:00.0

What's really misunderstood or not understood at all is that there's a testosterone receptor on every organ in the body.

0:07.0

So this does affect your brain, your cardiovascular system, your bone health, your muscle health, yes, your libido, mitochondrial biogenesis or oxidative stress.

0:17.2

These are things that affect your mitochondria and effectively how healthy your cells are.

0:21.2

And downstream, what does that mean for your overall body?

0:23.5

So big picture is that testosterone has a role all across your body.

0:32.8

Hello, fam.

0:33.9

Welcome to another episode of Better with Dr. Stephanie.

0:36.7

It's me, your host, Dr. Stephanie Estima. Today we are talking all about testosterone replacement therapy

0:42.8

for women. Now, certainly we are going to talk about this for men because it's very well

0:48.3

established in the literature. But if you are someone who is experiencing brain fog, you used to be able to make decisions and now

0:56.6

you feel like you are a former shell, you are a shell of your former self. If you are finding

1:01.3

that you're not able to make your squat numbers anymore or your deadlift numbers, your

1:05.4

strength in the gym is starting to deteriorate despite doing all the right things or things like sleep.

1:11.7

You notice that your sleep is trash no matter what you do and you have all the sleep hygiene

1:15.5

dialed in. This is going to be a conversation for you. My guest today is Shalin Shah. He is the

1:22.1

chief executive officer at Marius Pharmaceuticals where he led the development and the FDA approval of oral testosterone called Keizatrux.

1:31.0

This is the first oral testosterone therapy for men with low testosterone due to medical conditions.

1:36.9

Now, keep in mind that we talk a lot about off-label use of testosterone for females in this conversation,

1:43.6

because as of this recording in

1:45.6

North America currently there are no approved products for testosterone in women so a lot of our

1:50.4

conversation is around the off-label use and how to do that I understand that we now have in

1:56.2

Australia and yay the United Kingdom we have products that are available for females, but as of this

...

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