Saliva Protein Might Inhibit Intestinal Anarchy
Science Quickly
Scientific American
4.4 • 1.4K Ratings
🗓️ 10 March 2018
⏱️ 2 minutes
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| 0:00.0 | This is Scientific American's 60 Second Science. |
| 0:05.0 | I'm Christopher Intagiyata. |
| 0:07.0 | Every day, you produce one to two liters of spit. |
| 0:10.0 | It kick starts digestion and helps you swallow and it helps prevent bacterial infection in your mouth. |
| 0:15.4 | But that still seemed like a lot of energy put into something if it's only going to do that small task. |
| 0:21.4 | Esther Bullet, a biophysicist at the Boston University School of Medicine. |
| 0:25.6 | And we wondered whether there was something else that it was doing as well, that maybe it had a farther reach |
| 0:31.1 | than just preventing infections in the mouth. |
| 0:33.7 | So she and her team looked farther down the pipes, |
| 0:36.4 | and whether certain proteins and spit |
| 0:38.5 | might also disrupt the work of bad bugs in the gut. |
| 0:41.6 | They grew cells taken from the small intestine of a 51-year-old |
| 0:44.6 | woman and they also grew a batch of pathogenic E. coli bacteria, the kind that caused |
| 0:49.4 | traveler's diarrhea. The E. coli have little hair-like extensions on them, called |
| 0:54.0 | pealie, that grab on to the intestinal cells. But fewer of the E. coli were |
| 0:58.6 | able to successfully attach to the intestinal cells when a particular saliva protein called |
| 1:03.7 | his statin five was hanging around. You might think of the E. coli like |
| 1:07.6 | pirate ships trying to dock at a port. What the hisatin five does is |
| 1:11.7 | stop the pirate ships, the bad bugs, from using their ropes, the pely, to dock. |
| 1:17.0 | Because if you can't bind, then you can't start an infection. |
| 1:21.0 | So no adhesion, no infection, no disease. The study is in the journal of |
| 1:25.9 | infectious diseases. The salivary protein can be chemically synthesized, stored as a powder, |
... |
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