S1E29 / A Magic Bullet? Monoclonal Antibodies / James Crowe

EPIDEMIC with Dr. Celine Gounder

KFF Health News and Just Human Productions

Science, #Coronavirus, Health & Fitness, #Smallpox, Documentary, #Covid19, #Sarscov2, #Eradication, Life Sciences, Society & Culture, #Covid, Medicine

4.6 • 1K Ratings

🗓️ 16 June 2020

⏱️ 29 minutes

🔗️ Recording | iTunes | RSS

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Summary

"In our case, we're trying to transfer an antibody from one person to another. And it's actually a simpler idea because the recipient of an antibody RNA does not have to really respond to it. They just make it, and they have instant immunity." -Dr. James Crowe In today’s episode, our host Dr. Celine Gounder speaks with Dr. James Crowe, Director of the Vaccine Center at Vanderbilt Medical Center, about the next phase in antibody-based therapies, which is being spearheaded by Dr. Crowe’s lab at Vanderbilt. They are working on a technique to manufacture immunity in a test tube by isolating a single antibody for a disease that can be used to specifically target and fight that disease. They talk about the upcoming clinical trials of monoclonal antibodies for treatment of COVID-19, and how this method differs from convalescent plasma and vaccination. Finally, they discuss the next frontier- how science may soon take us beyond drug treatments and into a realm where our bodies are programmed to defeat a virus before we’ve ever encountered it… a true magic bullet. This podcast was created by Just Human Productions. We're powered and distributed by Simplecast. We're supported, in part, by listeners like you. #SARSCoV2 #COVID19 #COVID #coronavirus

Transcript

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0:00.0	I'm Dr. Saline Gounder and this is epidemic.
0:17.0	Today is Tuesday June 16th. The The Shenley Labritories,
0:35.0	of Shenley Laboratories,
0:37.0	producer of Penicillin Shenley and Shenley Pharmaceuticals
0:41.0	presents the Enore theater.
0:44.0	Back in the 1940s, you could tune into radio dramas about the lives of famous medical scientists,
0:50.0	Louis Pasteur, Florence Nightingale, and Paul Erlich.
0:54.0	The Encore Theater Play Tonight, Dr. Erlich's Magic Bullet.
1:00.0	Paul Erlich was a German scientist in the early 20th century.
1:06.0	He worked with Dr. Emil Bering, the Nobel Prize winning scientist who developed convalescent plasma.
1:12.0	The treatment we talked about last Tuesday in our series
1:15.6	of episodes on immunology.
1:17.5	The immunity is not a quality of the blood, but something in the blood, specific substances that are formed by the cells a chemical army which destroys bacteria and poisons
1:28.6	I'm beginning to see what you're getting at
1:31.0	This chemical army earlix talking about would end up being antibodies. Remember convalescent plasma or serum is when you take blood from someone immune to a virus or bacteria and give their antibody rich blood to another patient to help
1:44.8	them fight off the disease. The play based on Ehrlich's life has everything.
1:49.2	Suspense. A trial would bring everything into the open.
1:53.0	It would be the finish of Erlich in his so-called specific.
1:56.0	Science?
1:57.0	Do you see them, Emil?
1:58.0	Of course I see them.
1:59.0	The red rod-like shapes are the tuberco-basilai.
	...

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