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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Rosuvastatin Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Medicine, Education, Health & Fitness

4.9773 Ratings

🗓️ 7 October 2021

⏱️ 15 minutes

🧾️ Download transcript

Summary

On this episode, I discuss rosuvastatin pharmacology, adverse effects, drug interactions and pharmacokinetics.

Rosuvastatin is a hydrophilic statin which differs from some of the most commonly used statins like simvastatin and atorvastatin.

Rosuvastatin is minimally affected by CYP3A4 drug interactions so that is a small potential advantage over simvastatin and atorvastatin.

At dosages of 20-40 mg, rosuvastatin is considered a high intensity statin and can bring down LDL by over 50%.

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Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Eric Christensen.

0:05.5

Thank you so much for listening today. Go check out RealLife Pharmacology.com. If you haven't, go subscribe there.

0:14.0

With your email, you'll simply get a 31-page PDF on the top 200 drugs. A great little study guide, great little review if you've been

0:22.6

in practice for a while. And I highlight some of the most important things that I actually see

0:27.8

in clinical practice. I know it's hard sometimes to get relevant information when you look at

0:34.6

drug information handbooks and things like that. So again, go check that free resource out.

0:40.8

You'll simply get it for providing an email,

0:43.3

and we'll obviously get you updates when we've got new podcasts

0:46.3

and other content out available as well.

0:49.3

So let's get into the drug of the day today.

0:53.2

That is Rosuvastatin or Crestor.

0:56.1

I wanted to follow up after the previous episode with a torvastatin.

1:02.3

I thought it might be an easy thing to do.

1:04.9

If you're studying, preparing for cardiovascular topics, exams, boards, that type of thing, kind of keeping

1:13.9

these podcasts together a little bit. So with that said, Rosuvastatin, brand name, Crestor,

1:20.4

it is a statin medication, and it lowers cholesterol. Classification is an HMG-CA reductase inhibitor. And again, that's the

1:32.1

enzyme that really controls the speed or controls the process, primarily of that production of

1:40.7

cholesterol. Ultimately, what are we managing by lowering cholesterol?

1:47.7

We're reducing risk for like atherosclerosis,

1:52.0

cardiovascular disease, heart attack, strokes.

1:54.4

We're trying to prevent those things, basically by lowering cholesterol.

2:00.6

All right.

...

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