Ever since nicotinamide NAM was also shown to cure Pallagra,

both nicotinic acid N.A. and NAM have been collectively referred to as niacin, or vitamin B3,

though they are distinct compounds.

For example, NAM is not plagued by the same kind of hot flash reaction.

Facial flushing attributed to niacinamide in some older studies were likely due to a less

purified form contaminated with residual N.

The relative capacity of N.A versus NAM to generate NAD is unclear. Neither has been

shown to boost search-win activity, but both do extend the lifespan of sea elegance. I couldn't

find any longevity trials for N-A in rodents. However, NAM was put to the test and failed to

prolong the lives of mice.

What clinical effects might we expect in people?

Previously, I explored the proven anti-aging effects for topical nicotinamide on the skin

and the remarkable ability of oral nicotinamide to help prevent skin cancer.

I also noted it failed to prevent type 1 diabetes despite promising mouse data,

though it may help preserve residual function

and people newly diagnosed with type 1 diabetes,

but apparently not enough to affect blood sugar control.

What about its use as an NAD booster?

In those with mitochondrial myopathy, N.A. raised muscle NAD levels and improved mitochondrial and muscle function, but in healthy

individuals, muscle NAD levels didn't budge. However, the average age of individuals in the control

group was 50. What about an older adult whose muscle NAD levels might potentially be lower?

Four NAD precursors were tested in older adults, averaging in their 70s.

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