Restore Youthfulness & Vitality to the Aging Brain & Body | Dr. Tony Wyss-Coray

Huberman Lab

Scicomm Media

Life Sciences, Health & Fitness, Science

4.8 • 30.3K Ratings

🗓️ 23 February 2026

⏱️ 119 minutes

🔗️ Recording | iTunes | RSS

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Summary

Dr. Tony Wyss-Coray, PhD, is a professor of neurology at Stanford School of Medicine and Director of the Phil and Penny Knight Initiative for Brain Resilience who is discovering factors present in young blood and in exercised blood that can improve brain, heart, and other organ health. We discuss how different organs age at different rates and how to accurately measure biological aging. We also discuss the specific proteins found in blood when we are young and that are increased by things such as exercise, sunlight exposure, short-term fasting, specific foods, and social connection that can significantly increase vitality, restore youthful functioning of the brain and body, and potentially increase lifespan. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman David: https://davidprotein.com/huberman LMNT: https://drinklmnt.com/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Tony Wyss-Coray (00:03:00) Young vs Old Animals, Age-Related Disease (00:06:35) Blood Biomarkers, Young vs Old Humans, Alzheimer's Disease (00:12:50) Sponsors: David & LMNT (00:15:28) 'Young Blood' Factors, Rejuvenation, Stem Cells (00:20:15) Blood Banking; Dracula (00:23:10) Rates of Aging in Organs, Age Gap & Disease Risk; Risk Profiles & Therapies (00:33:02) NAD Levels & Aging, NMN Supplements (00:36:44) Vitality vs Longevity; Periods of Accelerated Aging (00:43:17) Sponsors: AG1 & Roka (00:45:22) Sunlight; Youthful Blood Factors, Exercise & Brain Function, Fasting (00:51:25) Exercise, Injury & Inflammation (00:56:18) Pro-health Factors, Klotho, GDF11, Stem Cell Injection Risk (01:02:35) Platelet-Rich Plasma (PRP); Exosomes (01:05:43) Smoking, EMFs, Plastics, Long-Term Accumulation, Fresh Foods, Organic Food (01:11:28) Sponsor: Function (01:13:16) Intermittent Fasting, Long-Term Fasting, Snacking (01:19:07) Sleep; Cerebrospinal Fluid (CSF) Factors & Cognitive Function (01:24:44) Exercise Type & Longevity; Exercise Enjoyment (01:32:02) Lifestyle Factors & Alzheimer's Risk; Cognitive Exercise; Chocolate (01:37:05) Alcohol & Social Connection; US vs European Food Culture (01:40:50) Deliberate Deep Breathing; Wearables, Sunlight & Artificial Light (01:49:13) Future Projects (01:56:40) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	For the first time, we could take an old brain,
0:02.2	and we could give factors from a young organism and ask,
0:05.9	is that going to change the age of the brain?
0:08.6	And that's indeed what it did.
0:10.2	So we saw that there are stem cells in the brain of these mice,
0:14.7	that they got reactivated, there was less inflammation,
0:18.8	more activity that we can measure in the brain.
0:22.6	And then most importantly, we actually saw that their memory function improved.
0:26.6	Welcome to the Huberman Lab podcast, where we discuss science and science-based tools for everyday life.
0:33.6	I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine.
0:42.8	My guest today is Dr. Tony Weiss-Corey.
0:45.5	Dr. Tony Weiss-Corey is a professor of neurology at Stanford School of Medicine,
0:49.4	and an expert in identifying factors that can help prevent and reverse organ degeneration and aging.
0:56.4	Today we discuss the factors that are present in young blood.
0:59.6	Yes, you heard that right.
1:01.1	And the factors that are present in blood after exercise
1:04.3	that have been shown to rejuvenate the brain
1:06.3	and other tissues in older individuals.
1:08.7	Dr. Tony Weiss-Coryy's lab has discovered several proteins that
1:12.1	are present in high amounts when we are young and that circulate in the blood and that diminish
1:16.8	with age. And if these are supplied to the aged body and brain, can reverse key features of aging,
1:23.1	including improved cognition, tissue recovery from stress, damage, and more.
	...

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