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Hacking Your ADHD

Research Recap with Skye: The Atomoxetine Trial

Hacking Your ADHD

William Curb

Mental Health, Health & Fitness

4.7779 Ratings

🗓️ 13 February 2026

⏱️ 13 minutes

🧾️ Download transcript

Summary

Welcome to Hacking Your ADHD. I'm your host, William Curb, and I have ADHD. On this podcast, I dig into the tools, tactics, and best practices to help you work with your ADHD brain. Today, I'm joined by Skye Waterson for our research recap series. In this series, we take a look at a single research paper and dive into what the paper says, how it was conducted, and try to find any practical takeaways.

In this episode, we're going to be discussing a paper called "Atomoxetine treatment strengthens an anti-correlation relationship between functional brain networks in medication-naive adults with attention deficit hyperactivity disorder: A randomized double-blind, placebo-controlled clinical trial." Yes, that's the full study name.

If you'd life to follow along on the show notes page you can find that at https://HackingYourADHD.com/272

https://tinyurl.com/56rvt9fr - Unconventional Organisation Affiliate link

https://tinyurl.com/y835cnrk - YouTube

https://www.patreon.com/HackingYourADHD - Patreon

 

Transcript

Click on a timestamp to play from that location

0:00.0

Welcome to Hacking your ADHD.

0:07.0

I'm your host, William Kerb, and I have ADHD.

0:10.0

On this podcast, I dig in the tools, tactics, and best practices to help you work with your ADHD brain.

0:15.0

Today I'm joined by Sky Waterston for our research recap series.

0:18.0

In this series, we take a look at a single research paper and dive into what the paper says, how it was conducted, and try and find any practical takeaways. In this episode, we're going to be discussing a paper called Automoxine Treatment, Strengths, and Anticorrelation Relationship between functional brain networks and medication, naive adults with attention deficit hyperactivity disorder, a randomized double-blind placebo controlled clinical trial.

0:39.2

Yes, that's the full study name.

0:40.8

It's quite a lot.

0:42.0

And this study is about this push-pull relationship between the default mode network and

0:46.4

the task positive network and then how admoxasine treats and can be effective in dealing

0:52.7

with it.

0:53.2

So let's get into it by kind of maybe jumping into

0:56.3

some of these terms that we're going to be talking about. Yeah, I think we should start with some terms.

0:59.9

So I will say as well, this paper is from 2015. So it's a bit of an older paper, but it was also the paper

1:06.9

that really nailed this topic in terms of what, you know, a randomized double-blind

1:15.5

placebo-controlled study, which basically means that they did this, well, let's talk about what

1:22.4

it is first, then we'll talk about how they did it. So take us through what the task mode is, the default mode and all that

1:29.1

stuff. Okay. So the default mode network, we've, you know, I've done episodes about this and we've

1:34.6

talked about it on the podcast before. And it's something I think is really interesting to discuss because

1:39.1

it's this like active part of your brain. So it's the regions of your brain that light up. And when we're,

1:46.7

when light up in the terms of that's what you see what's active during an MRI, which is we're

1:51.6

going to be talked about the study. But so it's this active during your rest, mind watering and like

1:57.1

self-referential thoughts. You know, you're kind of like, I'm chilling out and I'm daydreaming.

...

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