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ZOE Science & Nutrition

Recap: Is it time for you to try fasting? | Dr Valter Longo & Tim Spector

ZOE Science & Nutrition

ZOE

Nutrition, Science, Health & Fitness, Education

4.65.6K Ratings

🗓️ 9 December 2025

⏱️ 18 minutes

🧾️ Download transcript

Summary

Most of us have heard about the health benefits of fasting; from lowering disease risk to even slowing down ageing. The catch? Going without food is tough. Really tough. However, according to Dr. Valter Longo, it doesn’t have to be so hard. His pioneering research, including the development of the ‘fast-mimicking diet’, is making fasting more practical and accessible for everyone. Today, Valter joins Tim Spector and I to explain how a pause from food transforms the way our cells behave, and how you can make fasting part of your life. 🌱 Try our new plant based wholefood supplement - Daily30+ *Naturally high in copper which contributes to normal energy yielding metabolism and the normal function of the immune system 📚Books by our ZOE Scientists The Food For Life Cookbook Every Body Should Know This by Dr Federica Amati Food For Life by Prof. Tim Spector Ferment by Prof. Tim Spector Free resources from ZOE Live Healthier: Top 10 Tips From ZOE Science & Nutrition Gut Guide - For a Healthier Microbiome in Weeks  Better Breakfast Guide Have feedback or a topic you'd like us to cover? Let us know hereListen to the full episode here

Transcript

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0:00.0

Hello and welcome to Zoe Recap, where each week we find the best bits from one of our podcast episodes to help you improve your health.

0:09.0

Most of us have heard about the health benefits of fasting, from lowering disease risk to even slowing down aging.

0:17.0

The catch, going without food is tough. Really tough.

0:21.6

However, according to Dr. Volta Longo, it doesn't have to be so hard.

0:26.6

His pioneering research, including the development of the fast-mimicking diet,

0:31.6

is making fasting more practical and accessible for everyone.

0:34.6

Today, Volta joins Tim Specter and I to explain how a pause from food

0:39.0

transforms the way our cells behave and how you can make fasting part of your life.

0:46.2

I always challenge everyone with the question, find me anything that will revolutionize gene expression

0:53.4

more than fasting.

0:55.0

And I still haven't got anybody to even come up with something that they think could challenge.

0:59.0

Meaning if you fast a person for, let's say, five days, it'd be hard to find something else

1:05.0

that causes more changes in the body than those five days, right?

1:09.0

Of course, if you go longer, even more changes, but, but, you know, I say anything you

1:13.4

can do in five days.

1:14.8

So, so everything happens during fasting for obvious reasons, right?

1:18.6

So you now can no longer rely on energy coming from the outside.

1:23.5

You need to rely on energy come from inside.

1:26.7

And so the body slowly gets into a modality

1:30.5

where it starts burning fat

1:32.3

and relying on fatty acids and ketone bodies.

1:36.2

And ketone bodies are this, you know,

...

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