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The Quanta Podcast

Protein Blobs Linked to Alzheimer's Affect Aging in All Cells

The Quanta Podcast

Quanta Magazine

Physics, Life Sciences, Science

4.7640 Ratings

🗓️ 26 October 2022

⏱️ 23 minutes

🧾️ Download transcript

Summary

Protein buildups like those seen around neurons in Alzheimer’s, Parkinson’s and other brain diseases occur in all aging cells, a new study suggests. Learning their significance may reveal new strategies for treating age-related diseases. Read more at QuantaMagazine.org. Music is “Aimless Amos” by Rondo Brothers.

Transcript

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0:00.0

Welcome to Quantum Magazine's podcast.

0:06.0

Each episode, we bring you stories about developments in science and mathematics.

0:11.0

I'm Susan Vallett.

0:12.0

Before we begin, we want to acknowledge that this is the 200th episode of the Quanto Science Podcast.

0:19.0

Whether you've been with us since our first episode seven years ago, or if this is your

0:24.5

first time, thanks so much for listening.

0:28.2

And if you like this podcast, check out the other podcasts from Quantum Magazine, like

0:33.3

The Joy of Y and The Joy of X, both hosted by Stephen Strogetz, with a new season of the Joy of

0:40.2

Y coming up in 2023. The aging brains of people with Alzheimer's, Parkinson's, and other neurodegenerative

0:49.8

diseases have telltale aggregates of proteins in or around their neurons.

0:56.3

How these protein clumps might be harming the neurons is often still unclear, but they are

1:02.7

hallmarks of the conditions.

1:04.9

And until now, they have been associated almost exclusively with elderly brains. That's next.

1:11.6

Quantum Magazine is an editorially independent online publication

1:18.6

supported by the Simon's Foundation

1:21.6

to enhance public understanding of science.

1:34.2

A recent study by a team of Stanford University researchers suggests that protein aggregation may be a universal phenomenon in aging cells.

1:38.3

It could be involved in many more diseases of aging than was suspected.

1:43.1

Their discovery points to a new way of thinking about

1:46.2

what goes wrong in cells as they age, and potentially to new ways of staving off some

1:52.9

consequences of the aging process. Della David is a researcher on aging at the Babraham Institute

2:00.1

in Cambridge, England, who wasn't part of the study.

...

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