Progesterone is the biggest effect of progesterone on psychology in the short term is that when you take progesterone, your brain immediately synthesizes more allopregnanol, which is a molecule you talk about a lot on your channel.

This is something, I feel like I should almost, just the fact that I have you on would be a good tangent to go on about a post-finasteride syndrome and or people on TRT that could

otherwise benefit from exogenous progesterone supplementation. So I really like the idea

of using progesterone to kind of like backfill that steroidogenesis cascade that may

otherwise be deficient when you inhibit 5 AR. but then we were talking about how the negative

feedback of progesterone could then be problematic in terms of even just normal androgen

production which then you know could result in its own set of side effects so I feel like it's

more I feel like we agree on that it probably makes more sense for people who are replacing

their testosterone via exogenous means that it probably makes more sense for people who are replacing their testosterone via

exogenous means that it would be more of a thing to add in for those individuals and you said

you were having success with individuals who are implementing that currently yeah i think for people

who are not on TRT or you know they're not inhibiting their HPG system in some way.

In the future, hopefully there'll be some kind of chemicals that target the rate limiting step in the synthesis of neurosteroids in the brain, which is the TSPO receptor.

There are selective ligands for it. They just need to be produced.

That's what me and you got to get on.

That's what I mean, yeah.

But for people who are already on TRT, so when you go on TRT, you're the normal man's

progesterone is mostly synthesized in their gonads. So when you go on TRT, you also stop

the synthesis of progesterone. Number one. So just to get to the normal level of progesterone, you'd either have to take

HCG at a high, high dose, or you'd have to take progesterone, which we estimated to be at about

eight milligrams twice a day to replace the normal dose. But what's the value of progesterone? Other

than the fact that it's anabolic and that it enhances sex drive in the pattern I'm about to describe now.

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