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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Prochlorperazine Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 3 October 2019

⏱️ 12 minutes

🧾️ Download transcript

Summary

Prochlorperazine has several potential mechanisms of action. It can block dopamine and alpha receptors as well as have anticholinergic effects.



Prochlorperazine is classified as an antipsychotic and antiemetic. It is very seldom used as an antipsychotic in clinical practice and more used for its antiemetic effects.



Because of the anticholinergic activity of prochlorperazine, there is potential for dry mouth, dry eyes, urinary retention, constipation, and other anticholinergic effects.



Prochlorperazine does have the potential to have some alpha blocking activity. Keep an eye out for hypotension in patients who may be at risk.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist Eric Christensen.

0:06.7

And I did want to point out a lot of people have taken advantage. Several thousand people now

0:12.4

have taken advantage of the free resource at real life pharmacology.com. It's a 31 page PDF, top 200 drugs.

0:20.7

It was recently reached out by a fellow pharmacist who's teaching some pharmacy technicians,

0:27.0

and definitely they've found it to be a valuable resource in helping train, educate,

0:34.3

health care professionals to provide better care there and to really highlight important

0:39.6

pearls with regards to the top 200 drugs there.

0:43.8

So again, 31 page PDF, check it out, real-life pharmacology.com.

0:49.7

So again, I'm your host, Derek Christensen.

0:51.9

If you want to reach out to me, track me down at LinkedIn.

0:55.6

And I think that's going to be it for announcements today here.

0:59.7

So let's get into the drug.

1:02.3

Prochlorparazine is a medication brand name compazine.

1:08.5

I've also heard Compro used before as well in clinical practice.

1:13.1

And this is a bit of a complex medication, at least as far as a mechanism of action perspective

1:22.6

goes. So this drug is classified as an anti-medic also can be classified as an antipsychotic.

1:31.2

Now, I won't say that it's never used as an antipsychotic, but in, you know, 10 years approximately of clinical practice, I have never seen this medication used as an antipsychotic.

1:43.9

So there may be a patient out there somewhere, but again, this medication is primarily used for its anti-emetic, anti-nausea type purposes.

1:56.5

Now that mechanism of action.

1:59.5

So we've got some dopamine blocking activity at the D1 and D2 receptors.

2:06.1

And because of that dopamine blocking activity, that is kind of the classic mechanism of antipsychotics.

2:15.9

However, dopamine is an important molecule within the brain in the chemoreceptor zone.

...

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