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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Prazosin (Minipress) Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 19 January 2023

⏱️ 13 minutes

🧾️ Download transcript

Summary

On this episode, I discuss prazosin pharmacology, adverse effects, drug interactions and much more.



Prazosin is an alpha-blocker but lacks selectivity. A reduction in blood pressure is expected, but it is notorious for causing orthostatic hypotension.



Prazosin may be used off-label for nightmares, when this is the case, you will likely only see this drug dosed at bedtime.



Alpha agonist medications (such as pseudoephedrine and ADHD stimulants) may counteract the effects of prazosin.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist,

0:05.2

Derek Christensen. Thank you so much for listening. As always, go to real life pharmacology.com,

0:10.2

get your free 31-page PDF on the top 200 drugs. Great little refresher. I've also got some big

0:16.7

news coming to real-life pharmacology.com. I'm working on a free question bank, particularly for

0:25.2

folks in the beginning stages of their health care career, mostly geared towards nursing

0:30.9

pharmacology folks. So that is going to be absolutely free. Currently working on that as I'm releasing this podcast episode.

0:39.8

So come back, pay attention, real-life pharmacology.com.

0:43.3

Feel free to share that with all your friends, classmates, students, and things of that nature, too.

0:48.8

So with that announcement, let's get into the drug of the day.

0:53.1

Drug of the day today is

0:54.6

prasusin brand name of this medication is mini press now I would say I don't see

1:00.9

this medication used terribly often however I do see it from time to time for sure

1:08.1

and this drug is an alpha blocker.

1:11.8

It's got that ending Z-O-S-I-N-Zosin.

1:15.8

And it is a non-selective alpha blocker.

1:19.8

So the two primary areas where this is going to touch is blood vessels.

1:27.0

So that's a really, really important thing to think about.

1:30.0

And the urinary tract is another thing to think about there.

1:34.9

In addition to that, Prazacin has some activity in getting to the central nervous system.

1:40.4

The mechanism isn't quite totally understood, but we've got a few indications to think about.

1:46.2

So first indication, hypertension.

1:48.9

We're basically using an alpha blocker that's going to open up the vessels.

...

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