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Dhru Purohit Show

Overlooked and Shockingly Simple Tools to Assess and Mitigate the Risk of Alzheimer’s Disease with Dr. David Perlmutter

Dhru Purohit Show

Dhru Purohit

Medicine, Health & Fitness, Alternative Health

4.73.4K Ratings

🗓️ 4 August 2025

⏱️ 30 minutes

🧾️ Download transcript

Summary

This episode is brought to you by Momentous and AquaTru. According to today’s guest, the roots of Alzheimer’s are planted decades before symptoms appear. That means it’s never too early to take action. Today’s guest, Dr. David Perlmutter, shares powerful lifestyle strategies to protect your brain and lower your risk of neurodegenerative disease. Today on The Dhru Purohit Show, we’re revisiting one of our most talked-about moments with Dr. David Perlmutter to discuss research on the top four factors that can determine the risk of developing Alzheimer’s and his lifestyle tips for prevention. Dr. Perlmutter shares the tools we can use to analyze our brain’s energy use and discusses the importance of engaging in physically and mentally stimulating activities.  Dr. David Perlmutter is a Board-Certified Neurologist and five-time New York Times bestselling author. He serves on the Board of Directors and is a Fellow of the American College of Nutrition. He is the author of Grain Brain and Drop Acid. He serves as a member of the Editorial Board for the Journal of Alzheimer’s Disease. He has published extensively in peer-reviewed scientific journals, including Archives of Neurology, Neurosurgery, and The Journal of Applied Nutrition. In this episode, Dhru and Dr. Perlmutter dive into: How belly measurements can reveal metabolic health (01:21) Four key factors that determine Alzheimer’s risk (6:00) The impact of refined carbs vs. colorful foods on brain health (8:10) How blood pressure and nitric oxide affect cognitive function (11:08) The surprising connection between the oral microbiome and brain health (19:54) Tools to assess how efficiently the brain uses energy (22:54) How a sedentary lifestyle increases the risk of cognitive decline (25:12) Final thoughts and takeaways (27:34) Also mentioned: Full episode with Dr. David Perlmutter This episode is brought to you by Momentous and AquaTru Shower. Support your energy, bones, and resilience with The Women’s Three: Iron, Calcium, and Vitamin D3—formulated by experts, made for women. Head to livemomentous.com and use code DHRU for 35% off your first subscription. Right now, AquaTru is offering my community $50 off their new shower filter. Ready to upgrade your shower? Visit dhrupurohit.com/shower to experience the AquaTru Shower difference.  Sign up for Dhru’s Try This Newsletter Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

Hi, everyone. Drew Brode here. One of my main motivators in prioritizing my health, in addition to just

0:05.3

wanting to feel good day to day, is to protect my brain and my cognitive health, especially as I age.

0:11.7

And if you've ever wondered whether cognitive decline is truly preventable or how much control

0:17.5

we really have over our brain's destiny, today's episode is for you.

0:21.9

Today, I'm sharing a portion of my conversation with Dr. David Perlmutter on often overlooked

0:27.5

but shockingly simple tools that can help us assess and mitigate our risk for neurodegenerative

0:34.2

diseases like Alzheimer's disease. These aren't expensive test or obscure

0:39.8

biomarkers. They are things that you can actually do today. Now, a little bit about Dr. David

0:45.8

Perlmutter. He's a board certified neurologist and a five-time New York Times bestselling author.

0:50.9

He serves on the board of directors and is a fellow of the American College of Nutrition.

0:55.1

He also serves as a member of the editorial board of the Journal of Alzheimer's Disease and has

1:00.1

published extensively in peer-reviewed scientific journals, including the archives of neurology,

1:06.0

neurosurgery, and the Journal of Applied Nutrition. So let's dive right into my conversation on the key factors that determine our risk for Alzheimer's

1:15.3

with Dr. David Perlmutter.

1:20.8

You mentioned four things at the beginning and the opening his podcast that sounds so simple,

1:26.8

but are worth just touching

1:28.3

on for a minute when it comes to identifying our risk in developing these neurodegenerative

1:34.7

conditions. The first one was incredibly simple and most people listening to they probably

1:38.8

have it at home and it was a tape measure. What does a tape measure have to do with us understanding how well our body,

1:47.3

our body, and therefore our brain are running or not running? Very simple. Increased body fat

1:54.4

around the belly, around the middle is a marker of metabolic dysfunction. It's correlated with higher markers of inflammation,

2:03.7

increased resistance of the body's ability to use insulin,

...

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