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Huberman Lab

Optimize & Control Your Brain Chemistry to Improve Health & Performance | Episode 80

Huberman Lab

Scicomm Media

Science, Health & Fitness, Life Sciences

4.8 • 26.2K Ratings

🗓️ 11 July 2022

⏱️ 128 minutes

🧾️ Download transcript

Summary

In this episode, I explain the biological roles of the four major neuromodulators—dopamine, epinephrine (aka adrenaline), serotonin, and acetylcholine—and describe how these neuromodulators impact a wide variety of mental states and behaviors, including focus, creativity, motivation, drive, learning, alertness, mood, relationships, and feelings of well-being. Then, with that foundational understanding in mind, I describe a potent toolkit of science-supported behavioral, nutrition, and supplementation tools that can be used to increase baseline levels of individual neuromodulators and that can be modified for specific goals. This episode summarizes low-or-no-cost, actionable, science-based tools that can benefit anyone in order to enhance their levels of brain chemicals and improve mental health, physical health, and performance. Thank you to our sponsors AG1 (Athletic Greens): https://athleticgreens.com/huberman InsideTracker: https://insidetracker.com/huberman Maui Nui: https://mauinuivenison.com/huberman Supplements from Momentous https://www.livemomentous.com/huberman For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Optimizing Neurochemicals to Improve Health (00:03:40) Momentous Supplements (00:05:30) Sleep & Maintaining Healthy Metabolism (00:09:52) Tools: How to Wake Up Earlier, Night Owls (00:19:32) AG1 (Athletic Greens), InsideTracker, Thesis (00:22:05) Nervous System Overview (00:31:32) How Neuromodulators Work (00:34:24) Baseline Neuromodulator Levels, 3 Daily Phases (00:42:15) Hormones Modulate Neuromodulators (00:52:12) The 4 Major Types of Neuromodulators (01:01:45) Tool Kit 1: Increase Baseline Dopamine & Focus (01:08:52) Tyrosine-rich Foods & Dopamine (01:10:59) Dopamine Supplementation: Mucuna Pruriens, L-tyrosine & Phenylethylamine (01:16:00) Deliberate Cold Exposure & Dopamine (01:21:12) Tool Kit 2: Additional Tips to Increase Dopamine (01:26:10) Tool Kit 3: Increase Epinephrine (Adrenaline) & Alertness (01:34:34) Tool Kit 4: Increase Acetylcholine & Attention/Learning; Choline-rich Foods (01:37:29) Acetylcholine Supplements: Nicotine, Alpha GPC, Huperzine (01:44:47) Tool Kit 5: Behavior to Increase Focus & Acetylcholine (01:46:56) Tool Kit 6: Behavior to Increase Serotonin & Feelings of Well-being (01:50:51) Tools: Tryptophan-Rich Foods & Serotonin (01:53:31) Tools: Serotonin Supplements: Cissus Quadrangularis, 5-HTP, Myo-inositol (02:02:14) Use the Neurochemical Toolkit to Meet Individual Goals (02:06:44) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

Transcript

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0:00.0

Welcome to the Huberman Lab Podcast where we discuss science and science-based tools for everyday life.

0:09.0

I'm Andrew Huberman, a number of professor of neurobiology and ophthalmology at Stanford School of Medicine.

0:15.0

Today we are going to discuss your brain chemistry and how to control and optimize your brain chemistry for all aspects of mental health, physical health and performance.

0:25.0

Many times before on the Huberman Lab Podcast and frankly every time I'm a guest on another podcast, I get questions about science and science-based tools for things like enhancing sleep, enhancing focus, enhancing creativity, improving relationships, getting over grief and on and on.

0:41.0

All of which are valid questions and for which there are protocols that are based in science and that work, the first time and every time.

0:49.0

However, far more important than knowing a protocol is understanding why a given protocol works. That's why I'm always hammering on mechanism and explaining the cells and circuits and chemicals, at least to some detail so that people can understand not just what to do but why it works and therefore how to change your protocol as their life circumstances change or as goals change.

1:11.0

Now today we are going to go even a layer deeper. We're going to explore the foundations of your biology in your brain and body that allow any protocol to work because as it turns out, all of the protocols out there, whether or not it's a breathing protocol or a supplement or a prescription drug or an exercise routine, they all tap into and leverage a core set of just a few biological mechanisms.

1:37.0

That's right, beneath everything you are able to do and feel and indeed beneath every protocol that allows you to change for the better and optimize your mental health, physical health and performance, there's just a small subset of chemicals that you're leveraging toward that change.

1:53.0

So today we're going to talk about the four major pillars of neurochemistry that allow you to, for instance, be focused when you want to focus, that allow you to relax when you need to relax and destress, that allow you to optimize your sleep, that allow you to optimize your exercise routine or to work through a pain point in relationship or in career or in your relationship to yourself.

2:15.0

So what I can say for sure is that by the end of this episode, you will have a much richer understanding about how your brain and nervous system and indeed your entire body work and you will have a much firmer understanding as to which protocols and tools to reach for given your particular goals in the moment in the day across the week, across the month, across the year and indeed across your entire lifespan.

2:40.0

So what we're really going for today are principles, deeper understanding of why any given protocol works and we are also going to discuss specific protocols.

2:50.0

Some of those protocols I've discussed on previous episodes of the human lab podcast, but I must say many of the protocols and tools that I will discuss are brand new and based on research that I have not discussed at all simply because the research papers came out only recently or these are papers that I only recently unearthed.

3:08.0

In fact, I'm going to share with you two recent studies in a moment that are exceedingly important for optimizing your sleep and these are studies that again, I've never discussed in any episode on sleep or on any other podcast.

3:21.0

So by the end of today's episode, you're going to have far more knowledge about your biology and psychology than you did at the start and you'll be armed with many more tools and most importantly, principles so that you can navigate not just the tools presented on this podcast, but in the vast landscape of tools that are out there for the day.

3:37.0

So that's what I'm going to share with you today.

3:39.0

So I'm going to share with you two recent studies in a moment that are out there for mental health, physical health and performance.

3:43.0

The human lab podcast is proud to announce that we've partnered with momentous supplements. We've done that for several reasons.

3:49.0

First of all, the quality of their supplements is exceedingly high.

3:52.0

Second of all, we wanted to have a location where you could find all of the supplements discussed on the human lab podcast in one easy defined place.

4:00.0

So that's terrific whether you live in the US or you live abroad. Right now, not all of the supplements that we discuss on the human lab podcast are listed, but that catalog of supplements is being expanded very rapidly and a good number of them that we've talked about some of the more prominent ones for sleep and focus and other aspects of mental and physical health are already there.

4:26.0

And you can find them at live momentous.com slash Uberman every so often I come across a study or set of studies that I get so excited about that I start telling everybody in my immediate life.

4:36.0

And I insist on also sharing with you the listeners of this podcast because I find the information to be so incredibly interesting and actionable.

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