A new Narcan-resistant drug is being mixed into the already dangerous synthetic opioid fentanyl. The CDC has been tracking the concerning trend and found that xylazine, or "tranq," has become increasingly common in overdose deaths across the United States. In fact, according to the Drug Enforcement Administration, this animal tranquilizer with grotesque side effects is the deadliest drug threat our country has ever faced. New York City Special Narcotics Prosecutor Bridget Brennan joins to explain why xylazine overdose victims are often nearly impossible to save, how the sedative emerged as such a prominent threat, and what solutions government authorities should be looking at to stop the rapid spread of this drug. Many fear that with the rise of e-commerce and the continued expansion of big-box retailers, mom-and-pop shops across America will cease to exist as people become reliant on the Internet for all their needs. Both Walmart and Amazon have grown to become household names with same-day delivery and affordable prices. However, both retail giants are trying to break into each other's sphere by dabbling with the other's key strategy. Longtime business journalist and the author of 'Winner Sells All,' Jason Del Rey joins the Rundown to discuss standout strategies small businesses can adopt to remain competitive in the changing industry, how malls are redesigning themselves to draw in more revenue, and the biggest takeaways from his new book. Plus, commentary by Democratic strategist and former Biden campaign surrogate, Kevin Walling. Learn more about your ad choices. Visit megaphone.fm/adchoices