One Dose That Heals Addiction, PTSD, and Brain Injury? Dr. Nolan Williams on The Science of Ibogaine

The Dr. Hyman Show

Dr. Mark Hyman

Health & Fitness, Nutrition, Medicine

4.6 • 8.7K Ratings

🗓️ 3 September 2025

⏱️ 82 minutes

🔗️ Recording | iTunes | RSS

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Summary

For decades, psychiatry has relied on treatments that are slow and often ineffective. But what if one intervention could reset the brain, break the grip of addiction, and open the door to an entirely new model of care? On this episode of The Dr. Hyman Show, I sit down with Dr. Nolan Williams, a Stanford neuropsychiatrist pioneering new therapies for substance use disorders, depression, PTSD, and traumatic brain injury. We dive into these fascinating topics and more; watch the full conversation on YouTube or listen wherever you get your podcasts. You’ll learn: • Why ibogaine is unlike any other psychedelic—and how it could reset the brain • Its promise for treating substance abuse disorders and breaking cycles of addiction • The safety step that makes ibogaine treatment possible for real patients • Why psychiatry is shifting from trial-and-error to targeted brain circuits Talks like this remind me just how close we are to real breakthroughs in mental health. Dr. Williams calls it psychiatry 3.0. It’s a new era of treatments that actually heal the brain, and it gives me great hope for the future of medicine. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Sunlighten, Function Health,Timeline, AirDoctor and Pique. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.

Transcript

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0:00.0	Coming up on this episode of the Dr. Hyman Show. What you said blew my mind, which is that there's this
0:04.8	compound out there that can abruptly interrupt and withdraw from addiction that can help treat
0:10.6	PTSD, depression, traumatic brain injury, better than anything else we have out there on the market.
0:15.9	And orders of magnitude more. Dr. Nolan Williams is a triple board certifiedcertified neuropsychiatrist and founder of Stanford's
0:22.6	brain stimulation lab.
0:23.6	He's redefining how we treat depression, PTSD, and addiction.
0:27.6	Using brain stimulation, psychedelics, and neuroscience instead of meds.
0:31.6	I mean, there was a WHO statistic that really struck me, which is one out of two people will have a DSM diagnosis at some point in their lifetime.
0:40.3	I think this is just like a really paradigm shifting moment
0:42.3	where work like yours have really started to push the envelope and say,
0:45.3	hey, wait a minute, like we're thinking about mental illness all wrong.
0:48.3	We're talking about like one dose, one day, having an effect
0:51.3	to reverse your brain age by a year and a half at a month. That's pretty
0:54.4	remarkable. Is it dangerous for these people? When I'm working with my patients, the gut is ground
1:04.5	zero for health. It's where we absorb nutrients, regulate inflammation, and support immunity.
1:09.1	When your gut is out of balance, everything from energy to
1:11.7	skin to heart health can suffer. That's why I take seeds DSO1 daily symbiotic, a precision formulated
1:16.8	probiotic plus prebiotic that goes far beyond digestion. With 24 clinically studied strains and a
1:22.1	unique pomegranate-based prebiotic, DSO-1 supports gut barrier integrity, immune function,
1:26.8	and even heart and skin health through the gut liver and gut skin axis. What's especially exciting is, DSO1 supports gut barrier integrity, immune function, and even heart and skin health
1:27.9	through the gut liver and gut skin axes. What's especially exciting is that DSO1 is clinically
1:32.4	proven to promote short chain fatty acid production. These are critical compounds that help
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