Oct 10 2025 This Week in Cardiology
This Week in Cardiology
Medscape Podcasts
4.9 • 963 Ratings
🗓️ 10 October 2025
⏱️ 26 minutes
🧾️ Download transcript
Summary
GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I. Listener Feedback
HYPERION trial https://www.nejm.org/doi/10.1056/NEJMoa2508170
ZENITH trial https://www.nejm.org/doi/full/10.1056/NEJMoa2415160
II GLP1 Use in HFrEF
Effects of GLP-1s in Patients With HFrEF https://doi.org/10.1016/j.jchf.2025.102573
FIGHT Study https://jamanetwork.com/journals/jama/fullarticle/2540402
FIGHT Study Post-hoc Analysis https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14862
Substudy of EXSCEL Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.119.041659
III LA Posterior Wall Isolation Saga
Failure of PW Wall Isolation by PFA with Epicardial Mapping https://doi.org/10.1016/j.jacep.2025.08.017
IV Peridevice Leaks After LAAO
IMPRESSION LAAC Study https://doi.org/10.1016/j.jacep.2025.08.014
V Post Cardiac Surgery AF
Monitoring of New-Onset AF After CABG https://jamanetwork.com/journals/jama/fullarticle/2839710
PACES trial https://clinicaltrials.gov/study/NCT04045665
VI TEE vs ICE Before AF ablation
ICE vs TEE Study https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
Transcript
Click on a timestamp to play from that location
| 0:00.0 | You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology. |
| 0:05.7 | This podcast is intended for health care professionals only. |
| 0:08.8 | Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape. |
| 0:14.9 | Hi, everyone. |
| 0:16.4 | This is John Mandrola from the Heart.org Medscape Cardiology, |
| 0:20.1 | and this is this week in |
| 0:21.8 | cardiology for October 10th, 2025. |
| 0:25.8 | This week, some listener feedback, some corrections, GLP1 use in Hepreff patients, left atrial |
| 0:32.7 | posture wall isolation, peri device leaks for left atrial appendage occlusion, new findings in post-cardiac |
| 0:39.9 | surgery, AFib, and imaging before a-fablation. First, some listener feedback. I received two emails |
| 0:48.4 | about my coverage of a study of prophylactic pacing after Tavi in patients who have scary, gnarly conduction disturbances. |
| 0:57.0 | The study was actually a sub-study from the promote protocol from a Quebec group, |
| 1:01.8 | which overall is a prospective application of an expert panel algorithm, and it's designed to deal |
| 1:08.2 | with conduction disturbances after Tavi. The specific paper in Jack, first author, Quentin Fisher, |
| 1:14.6 | looked at 80 of 329 patients who had permanent pacemaker after Tavi. |
| 1:20.0 | These 80 were put in prophylactically. |
| 1:22.6 | The authors found that clinical outcomes at a month were similar |
| 1:25.6 | in the prophylactic versus non-prophylactic patients. |
| 1:29.1 | However, pacing percentage was dramatically lower in the prophylactic patients, 2% versus 73%, |
| 1:36.6 | as was the number of patients with pacing less than 1%, 46% versus 14%. |
| 1:43.9 | The authors concluded that these findings would question the systematic use of prophylastic pacing. |
| 1:51.2 | And I pushed back in the comments because being wrong about not pacing someone who then |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Medscape Podcasts, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Medscape Podcasts and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2026.