Obese Dad's Sperm May Influence Offspring's Weight
Science Quickly
Scientific American
4.4 • 1.4K Ratings
🗓️ 4 December 2015
⏱️ 2 minutes
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| 0:00.0 | This is scientific American's 60 second science. I'm Christopher Intalyata. Got a minute? |
| 0:07.0 | Just below the Arctic Circle in northern Sweden sits a town called Evercoliques. |
| 0:12.0 | It's home to only about a thousand people, but those inhabitants were the subjects of a seminal study in human genetics. |
| 0:19.0 | The research suggested that what our parents or even our grandparents ate, whether they grew up during feast or even our grandparents ate, |
| 0:23.0 | whether they grew up during feast or famine, |
| 0:25.0 | could actually affect our risk of heart disease and diabetes. |
| 0:29.0 | It shows that either caloric restriction or excess of food can send depending on the |
| 0:36.8 | window of your own development a similar message to the next generation. |
| 0:42.1 | Romaine Barres, a molecular biologist at the University of Copenhagen. |
| 0:46.0 | That transgenerational message is sent, of course, through sperm and eggs. |
| 0:51.0 | So, Barres and his colleagues compared the sperm of 13 Lean versus 10 obese men. |
| 0:56.4 | And they found that the heavyweights had epigenetic changes to their sperm, meaning additional |
| 1:00.6 | chemical groups on their DNA that affect how genes are expressed. |
| 1:05.2 | And many of those changes were to sequences known to affect brain development, including genes |
| 1:10.0 | that regulate appetite. |
| 1:12.1 | But the changes weren't permanent because when the researchers studied the sperm of men who |
| 1:15.4 | underwent weight loss surgery, they found that many of those genetic alterations reversed |
| 1:20.4 | post surgery, especially the ones in areas related to appetite control. The study is in the |
| 1:26.0 | journal Cell metabolism. The big question now is how much those epigenetic changes actually |
| 1:31.4 | influence the next generation. |
| 1:33.0 | Barres is now comparing father's sperm to the cord blood of their babies to find out. |
| 1:38.0 | But the finding suggests a mechanism by which our actions, our what should you be eating. |
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