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This Week in Cardiology

Nov 14 2025 This Week in Cardiology

This Week in Cardiology

Medscape Podcasts

Science, Medicine, Health & Fitness

4.9 • 963 Ratings

🗓️ 14 November 2025

⏱️ 37 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's podcast.

This podcast is intended for healthcare professionals only.

To read a partial transcript or to comment, visit:

https://www.medscape.com/twic

I Listener Feedback

Why I Believe Fish Oil's Big CV Benefit in Dialysis Patients https://www.medscape.com/viewarticle/why-i-believe-fish-oils-big-cv-benefit-dialysis-patients-2025a1000uzg

  • PISCES trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513032

II PCSK9 Inhibitor News

In Global Trial, PCSK9 Inhibitor Provides Major Protection Against First CV Event https://www.medscape.com/viewarticle/global-trial-pcsk9-inhibitor-provides-major-protection-2025a1000uzp

  • VESALIUS-CV trial https://www.nejm.org/doi/full/10.1056/NEJMoa2514428
  • ODYSSEY trial https://www.nejm.org/doi/full/10.1056/NEJMoa1801174
  • FOURIER https://www.nejm.org/doi/full/10.1056/NEJMoa1615664
  • Anish Koka Tweet on LDL-lowering https://x.com/anish_koka/status/1987280506937909326?s=20

III Beta-Blockers After MI and John Cleland

  • Beta-Blockers after MI with normal EF https://www.nejm.org/doi/full/10.1056/NEJMoa2512686
  • REBOOT-CNIC trial https://www.nejm.org/doi/full/10.1056/NEJMoa2504735
  • REDUCE AMI trial https://academic.oup.com/ehjcvp/article/9/2/192/6895544?login=false
  • ABYSS trial https://www.nejm.org/doi/full/10.1056/NEJMoa2404204
  • CAPITAL RCT trial https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199347
  • Beta-Blockers after MI with mildly reduced EF https://pubmed.ncbi.nlm.nih.gov/40897190/
  • John Cleland Clinical Outlook https://www.nature.com/articles/s41569-025-01228-w

IV Left Atrial Appendage Closure – The CLOSURE-AF trial

Percutaneous LAAC in AF Falls Short Again in CLOSURE-AF https://www.medscape.com/viewarticle/percutaneous-left-atrial-appendage-closure-af-falls-short-2025a1000uzu

  • Prague-17 Trial https://www.jacc.org/doi/10.1016/j.jacc.2020.04.067
  • OPTION trial https://www.nejm.org/doi/full/10.1056/NEJMoa2408308

V Oral AC after AF ablation – the OCEAN Trial

Anticoagulation After AF Ablation: The OCEAN Trial Still Leaves Questions https://www.medscape.com/viewarticle/anticoagulation-after-af-ablation-ocean-trial-still-leaves-2025a1000v4t

  • OCEAN Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2509688
  • ALONE-AF trial https://jamanetwork.com/journals/jama/fullarticle/2838294

You may also like:

The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington

Questions or feedback, please contact news@medscape.net

Transcript

Click on a timestamp to play from that location

0:00.0

You're listening to This Week in Cardiology from the heart.org, Medscape Cardiology.

0:05.7

This podcast is intended for health care professionals only.

0:08.8

Any views expressed are the presenters' own and do not necessarily reflect the views of WebMD or Medscape.

0:14.9

Hi, everyone.

0:16.5

This is John Mandrola from the heart.org, Medscape Cardiology.

0:24.9

And this is this week in cardiology for November 14th, 2025.

0:31.2

This week, I'll do some listener feedback on that remarkable Pisces trial last week.

0:36.7

American Heart Association meeting news, including a big PCSK-9 inhibitor trial,

0:40.7

beta blocker, post-MI, left atrial appendage closure, and post-AF ablation anticoagulation use. First, some listener feedback on the Pisces

0:48.2

trial. This was fish oil and patients on haemodialysis, and it found a clinically meaningful, statistically robust,

0:56.1

43% reduction in a mace endpoint over a corn oil placebo.

1:01.6

All components of the endpoint were reduced, including cardiac death.

1:05.9

I hemmed and hawed on this, and I scratched my head because, come on, I thought.

1:10.4

We aren't sure fish oil

1:11.6

works in the general population and we know nothing works in hemodialysis patients, not statins,

1:17.4

not marras, not ICDs. How do we expect fish pills to shred CV outcomes in patients on

1:24.4

hemodialysis? But the Pisces data are remarkable.

1:29.6

And there, we don't have any other data coming, so I leaned on saying I would accept the

1:34.0

trial results, and if it were me, I would prescribe hemodialysis patients these fish pills

1:40.3

because there's little downside.

1:42.9

But I received an excellent critical appraisal from Dr. Richard

1:46.8

Bogle from London. He makes four points and it's really a tour de force of learning, so I'm

...

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