4.2 • 639 Ratings
🗓️ 3 October 2016
⏱️ 3 minutes
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0:00.0 | Understanding the human body is a team effort. That's where the Yachtel group comes in. |
0:05.8 | Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years. |
0:11.0 | Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program. |
0:19.6 | To learn more about Yachtolt, visit yawcult.co. |
0:22.7 | .jp. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacult. |
0:33.5 | This is Scientific Americans' 60-second science. I'm Steve Merski. Got a minute? |
0:39.6 | The 2016 Nobel Prize in Physiology or Medicine goes to Yoshinuri Osumi of Japan for his discoveries of mechanisms of what's known as autophagy. |
0:50.5 | Break the word down and you get auto and phagy from the Greek for self, auto, and eating phagian. |
0:57.4 | So self-eating. |
0:59.1 | Autophagy refers to the process in cells whereby they destroy themselves and send the parts out for recycling. |
1:05.9 | Cells do this by enclosing their contents in tiny sacks called vesicles. |
1:10.6 | Those vesicles then get transported to |
1:12.7 | an organelle within the cell called the lysosome, where the sacks get degraded and the contents |
1:17.7 | are made available for reuse. Autophagy had been observed a half century before Osumi's work in the |
1:23.7 | 1990s while at the University of Tokyo. But it was his research that made clear its |
1:28.7 | fundamental importance. He did that work with baker's yeast. One way he made his discoveries was to |
1:34.4 | interfere with the process and thus see vesicles involved in autophagy start to build up. This action |
1:40.9 | proved that yeast cells performed autophagy. He went on to identify 15 genes crucial for the process. |
1:48.6 | Need quick fuel for energy? Autophagy makes that fuel available fast. Need raw materials for maintenance |
1:55.2 | in other cells. Autophagy gets those materials into the system so the body can respond to starvation and other |
2:02.1 | stresses. Infected, autophagy plays a role in capturing and killing bacteria and viruses. It |
2:08.8 | clears out damaged proteins and organelles, thus helping to fight the effects of aging. At the other |
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