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This Week in Startups

Next Unicorns: Developing drugs to extend dog lifespans with Loyal CEO Celine Halioua | E1799

This Week in Startups

Jason Calacanis

Technology

4.21.4K Ratings

🗓️ 30 August 2023

⏱️ 65 minutes

🧾️ Download transcript

Summary

This Week in Startups is brought to you by…

Fount. Do you want access to the performance protocols that pro athletes and special ops use? With Fount, an elite military operator supercharges your focus, sleep, recovery, and longevity, all powered by your unique data. Want a true edge in work and life? Go to fount.bio/TWIST for $500 off.

LinkedIn Jobs. A business is only as strong as its people, and every hire matters. Go to http://linkedin.com/unicorn to post your first job for free. Terms and conditions apply.

Catalog. Stop wasting time and money with expensive design firms and unreliable freelancers! Get fast, 3-day turnarounds for a flat monthly fee with Catalog! Get $1200 off right now at https://trycatalog.com/twist

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Today’s show:

Loyal CEO and Founder Celine Halioua joins Jason to discuss developing drugs that delay dog aging (10:19), lessons learned as a solo founder (49:34), and much more!

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Time stamps:

(0:00) Loyal CEO Celine Halioua joins Jason

(1:43) The human dream of achieving life extension

(4:37) Celine’s background

(8:48) Fount - Get $500 off at https://fount.bio/twist

(10:19) Why Celine decided to start with a focus on dogs

(16:43) Wegovy, Ozempic, and the category of drugs that Loyal is developing

(20:44) Breaking down how the drugs work and the consequences of selective breeding

(24:21) LinkedIn Jobs - Post your first job for free at https://linkedin.com/unicorn

(25:36) Stem cell therapy and the placebo effect

(33:29) Environmental factors to consider in drug development

(37:05) The path to commercialization

(39:27) Catalog - Get $1200 off right now at https://trycatalog.com/twist

(40:56) Staying intellectually curious and the path to commercialization continued

(46:11) Hitting Series A milestones with less than $500K of the original $5M raised in seed round

(49:34) Lessons learned as a solo founder

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Follow Celine: https://twitter.com/celinehalioua

Check out Loyal: https://loyalfordogs.com/

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Read LAUNCH Fund 4 Deal Memo: https://www.launch.co/four

Apply for Funding: https://www.launch.co/apply

Buy ANGEL: https://www.angelthebook.com

Great recent interviews: Steve Huffman, Brian Chesky, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland, PrayingForExits, Jenny Lefcourt

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Twitter: https://twitter.com/jason

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Transcript

Click on a timestamp to play from that location

0:00.0

There's something about being a solo act. I tell people like I'm Bob Dylan. I don't play well in a band and now I'm forced to be in a band with you all in podcast.

0:07.1

I can tell you it is not my natural state of being like.

0:10.6

You know I am the obvious of the front guy. I'm the lead singer. I just want to play the songs and I want to play the songs the way I want to play them. I want to play them correctly.

0:17.6

And then when you know somebody wants to do it some a different and then they want to be the lead singer. It's like the kid be two lead singers, you know, like you can sing a verse but like the dark player you're the bass player.

0:27.6

You're the drummer like do your job like and I agree with you. Like I think we're certain people.

0:33.8

You got to be the solo founder and you can go faster. But it's very rare. And then at the early stage having multiple ones. You know why actually this whole thing started with co-founders.

0:43.6

It's that's it. You know that it's in the interest of the investors this weekend. Startups is brought to you by

0:50.9

Fount. Do you want access to the performance protocols that pro athletes and special ops use with Fount and elite military operator supercharges your focus, sleep, recovery and longevity all powered by your unique data.

1:07.4

Want a true edge in work in life? Go to Fount.bio slash twist for $500 all linked in jobs. A business is only as strong as its people and every higher matters.

1:19.4

Post your first job for free at linkedin.com slash unicorn and catalog stop wasting time and money with expensive design firms and unreliable freelancers.

1:31.8

Get fast three day turnarounds for a flat monthly fee with catalog.

1:36.9

Get $1200 off right now at try catalog.com slash twist. Hey, everybody. Welcome to this week in startups.

1:45.6

And we all want to live longer, right? Life extension has been the dream of technologists, alchemists, religious people and humans since we existed. We all want to get a couple of extra years. And

1:57.9

remember Alta slabs raising three billion from Jeff Bezos, Sherry Milner, a bunch of folks. Startups are starting to use biotech solutions, AI, big data to look at diseases and try to fight agent.

2:12.2

Well, today on the program, we got a slightly different take on life extension. They're working a bit backwards. Planets to start with my favorite creatures on planet earth, dogs.

2:22.8

And eventually use the learnings there to develop life extension treatments for humans. And I think this makes the most sense to me because dogs are so much better than humans. So why the strategy well FDA approval for life extension drugs.

2:37.0

In dogs about 50 times less expensive than for humans. And you can tell if it works much faster because dogs have such a shorter lifespan than humans do.

2:45.1

So Selene Hollywood is the founder and CEO of loyal. Selene, I love dogs. Thanks for starting this company.

2:53.5

Absolutely. I'm why they're not a cat person.

2:56.2

Cat people are the worst. I think we all agree on that. And once you get to two or more cats, specifically three, you know, something's going very, very wrong in your life.

3:07.8

Now owning multiple dogs, like I do too, that's completely permissible. And when I retire, my wife and I plan to start a bulldog rescue. That is our retirement plan. So in 20 years old, so sweet.

3:19.1

Yeah. Dogs, almost by definition, if you get one, you're signing that contract that they're going to you're going to bury them. And they're not going to bury you.

...

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