New NASA Science Head, Climate and Fungus, Whiskey Fungus, Animal Testing Alternatives. March 24, 2023, Part 2
Science Friday
Science Friday and WNYC Studios
4.4 • 6.4K Ratings
🗓️ 24 March 2023
⏱️ 47 minutes
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| 0:00.0 | This is Science Friday. I'm Charles Berkwist. |
| 0:02.5 | And I'm Flora Lickman. |
| 0:04.2 | Last week on the show, we talked about how pharma companies are using artificial intelligence |
| 0:08.6 | to speed up the drug research and development pipeline. |
| 0:12.2 | And this week, we're zeroing in on another part of that process. |
| 0:16.2 | Animal testing. Before a new drug can begin clinical trials in humans, it gets tested on animals. |
| 0:22.6 | But things are changing. |
| 0:24.2 | Late last year, Congress passed the FDA Modernization Act 2.0, which cleared the way for new drugs to skip animal testing. |
| 0:32.4 | But can we expect to phase out animal testing altogether? |
| 0:36.3 | And what technologies might make that possible? To help us |
| 0:39.4 | answer those questions and more is my guest, Dr. Thomas Hartung, Director of the Johns Hopkins |
| 0:44.4 | Center for Alternatives to Animal Testing, based in Baltimore, Maryland. Dr. Hartung, welcome |
| 0:49.8 | to Science Friday. Thanks for having me. Okay, so what is driving this push to phase out animal |
| 0:56.0 | testing for drugs? Is this about ethical concerns or for scientific or for safety reasons? |
| 1:03.1 | It is for all of these and also for economical reasons. You have to imagine we are not 70 kilogram |
| 1:08.4 | rats. A lot of wrong decisions have been based on this |
| 1:12.4 | wrong assumption. Pharma companies fail in 95% of the cases they get something into humans. |
| 1:19.4 | They fail in 95% of the cases. Yeah, that's the failure rate of clinical trials. |
| 1:24.9 | Wow. And if we have anything which is more relevant to humans, which makes them spend their money |
| 1:30.6 | on better drugs, they want to go for it, even though we have learned the hard way for |
| 1:37.0 | drugs like Alzheimer, that very often our animal models have been so misleading. |
| 1:41.3 | We could cure tons of animals, but we cannot cure patients. |
... |
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